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CAS No.: | 202409-33-4 |
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Name: | Etoricoxib |
Article Data: | 44 |
Molecular Structure: | |
Formula: | C18H15ClN2O2S |
Molecular Weight: | 358.848 |
Synonyms: | 5-Chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine;Algix;Arcoxia;Etobrix;Etocox; |
EINECS: | 682-421-5 |
Density: | 1.298 g/cm3 |
Melting Point: | 134-135 °C |
Boiling Point: | 510 °C at 760 mmHg |
Flash Point: | 262.2 °C |
Appearance: | off-white powder |
Hazard Symbols: | T |
Risk Codes: | 22-24 |
Safety: | 36/37-45 |
PSA: | 68.30000 |
LogP: | 5.25670 |
etoricoxib hydrochloride
etoricoxib
Conditions | Yield |
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With sodium hydrogencarbonate In dichloromethane; water at 10 - 20℃; for 0.5h; Reagent/catalyst; Large scale; | 96.5% |
methyl iodide
etoricoxib
Conditions | Yield |
---|---|
Stage #1: 4-(5-chloro-6'-methyl-[2,3'-bipyridin]-3-yl)benzenesulfinic acid With tetra-(n-butyl)ammonium iodide In tetrahydrofuran at 65℃; for 0.333333h; Stage #2: methyl iodide In tetrahydrofuran at 65℃; for 2h; Cooling with liquid nitrogen; | 95% |
5-chloro-3-(4-methylsulphonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine
etoricoxib
Conditions | Yield |
---|---|
With sodium molybdate; sulfuric acid; dihydrogen peroxide In methanol at 55℃; for 0.25h; | 94% |
With oxygen; uranyl(VI) acetate dihydrate In o-xylene; water; acetonitrile at 20℃; under 760.051 Torr; Schlenk technique; Irradiation; | 91% |
With diethylene glycol dibutyl ether; oxygen at 110℃; for 20h; Green chemistry; | 78% |
1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone
etoricoxib
Conditions | Yield |
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With potassium hydroxide In acetonitrile at 80℃; for 8h; Concentration; Inert atmosphere; | 89% |
With caesium carbonate In tetrahydrofuran at 20℃; for 3h; | 82% |
1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone
etoricoxib
Conditions | Yield |
---|---|
Stage #1: 1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone With potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 0.25h; Inert atmosphere; Stage #2: N-(2-chloro-3-(dimethylamino)allylidene)-N-methylmethanaminium hexafluorophosphate(V) With acetic acid In tetrahydrofuran at 20 - 25℃; for 2.5h; Inert atmosphere; Stage #3: With ammonium hydroxide In tetrahydrofuran at 60 - 65℃; for 1.5h; Inert atmosphere; | 84.4% |
With methanesulfonic acid; ammonium acetate; propionic acid In toluene at 25 - 75℃; for 14 - 16h; Reflux; |
2,5-dichloro-3-[4-(methylsulfonyl)phenyl]pyridine
etoricoxib
Conditions | Yield |
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palladium | 79% |
1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone
etoricoxib
Conditions | Yield |
---|---|
Stage #1: 1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone With potassium tert-butylate In tetrahydrofuran at 25 - 30℃; for 1h; Stage #2: 2-chloro-1,3-(bis-piperidinyl)trimethinium hexafluorophosphate In tetrahydrofuran at 30 - 55℃; Product distribution / selectivity; | 75.9% |
formamide
1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone
etoricoxib
Conditions | Yield |
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With methanesulfonic acid In 1,2-dichloro-ethane at 80 - 100℃; for 24h; | 73% |
etoricoxib
Conditions | Yield |
---|---|
With ammonium hydroxide In tetrahydrofuran at 60 - 65℃; Inert atmosphere; | 72.1% |
With ammonium hydroxide In tetrahydrofuran for 5h; cyclocondensation; Heating; |
(6-methylpyridin-3-yl)boronic acid
etoricoxib
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In 1,4-dioxane; water at 80℃; for 8h; Suzuki Coupling; chemoselective reaction; | 71% |
Molecule structure of Etoricoxib (CAS NO.202409-33-4):
IUPAC Name: 5-Chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine
Molecular Weight: 358.8419 g/mol
Molecular Formula: C18H15ClN2O2S
Density: 1.298 g/cm3
Melting Point: 134-135 °C
Boiling Point: 510 °C at 760 mmHg
Flash Point: 262.2 °C
Index of Refraction: 1.6
Molar Refractivity: 94.65 cm3
Molar Volume: 276.4 cm3
Surface Tension: 49.6 dyne/cm
Enthalpy of Vaporization: 75.11 kJ/mol
Vapour Pressure: 5.17E-10 mmHg at 25 °C
XLogP3-AA: 3.3
H-Bond Acceptor: 4
Rotatable Bond Count: 3
Exact Mass: 358.054276
MonoIsotopic Mass: 358.054276
Topological Polar Surface Area: 59.9
Heavy Atom Count: 24
Canonical SMILES: CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl
InChI: InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-13)24(2,22)23/h3-11H,1-2H3
InChIKey: MNJVRJDLRVPLFE-UHFFFAOYSA-N
Product Categories: Osteoarthritis and Rheumatoid Arthritis; Intermediates & Fine Chemicals; Pharmaceuticals
Etoricoxib (CAS NO.202409-33-4) is a non-steroidal anti-inflammatory drug (NSAID). It is used for treating the diseases such as rheumatoid arthritis, psoriatic arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout.
Etoricoxib (CAS NO.202409-33-4) is also named as 5-Chloro-6'-methyl-3-(p-(methylsulfonyl)phenyl)-2,3'-bipyridine ; Arcoxia ; Etoxib ; Etropain ; Kingcox ; L-791456 ; MK 0663 ; MK 663 ; Tauxib ; Torcoxia ; UNII-WRX4NFY03R ; 2,3'-Bipyridine, 5-chloro-6'-methyl-3-(4-(methylsulfonyl)phenyl)- . Etoricoxib (CAS NO.202409-33-4) is off-white powder.