Detail of "2038-57-5"

Reference

Reduction of carboxylic acids, carbonyl compounds and the related compounds with samarium diiodide

Reduction of carboxylic acids, carbonyl compounds and the related compounds with samarium diiodide. (II). Kudo, T.; Kamochi, Y. (Daiichi Coll. Pharm. 2038-57-5 and 100-51-6 are also occured in this study. Sci., Kukuoka 815, Japan). Kidorui, 18, 150-1 (Japanese) 1991. CODEN: KIDOEP. ISSN: 0910-2205. DOCUMENT TYPE: Journal CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) Amides e.g. PhCONH2 were reduced with SmI2 in basic medium at room temp. to the corresponding alcs. e.g., PhCH2OH as the major products accompanied by amines e.g., PhCH2NH2. In these redns., compared with the tested bases, such as LiNH2, LiOMe and KOH, there was no remarkable difference in yields of alc. The similar redn. of oximes e.g., PhCH:NOH afforded the corresponding amines e.g., PhCH2NH2 in moderate yields. .

Adrenergic agents

Adrenergic agents. 5. Conformational analysis of 1-alkylamino-3-aryloxy-2-propanols by proton magnetic resonance studies. Implications relating to the steric requirements of adrenoreceptors. Jen, Timothy; Kaiser, Carl (Res. Dev. Div., Smith Kline and French Lab., Philadelphia, Pa., USA). J. Med. Chem.In this article, certain chemicals are used. Some of their cas registry numbers are 2038-57-5 and 62312-90-7 , 20(5), 693-8 (English) 1977. CODEN: JMCMAR. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 22 NMR conformational anal. showed that salts of 1-alkylamino-3-aryloxy-2-propanols in a nonpolar solvent had a stable rigid conformation with 20 intramol. H bonds, forming a 6-5 bicyclic chelated structure. Comparison of stereomodels of this rigid conformer with the preferred trans rotamer of adrenergic phenylethanolamines, e.g., isoproterenol, indicated all positions of the Ph ring, Ph-O or Ph-C bonds, and NH4+ groups of both chem. classes to be superimposed. A major difference between the 2 chem. species is the relative steric orientation of the alc. OH groups. Structure-activity relations and steric requirements for receptor selectivity are discussed. .