Detail of "20398-34-9"

Reference

Possible feed-back inhibition of noradrenaline release by purine compounds

Possible feed-back inhibition of noradrenaline release by purine compounds. Enero, Maria A.; Saidman, B. Q. (Inst. Invest. Farmacol., Cons. Nac. Invest. Cient. Tecn., Buenos Aires, Argent.). Naunyn-Schmiedeberg's Arch. Pharmacol., 297(1), 39-46 (English) 1977. CODEN: NSAPCC. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 13 The contractile responses to transmural stimulation of, and the overflow of tritium from the rat portal vein prelabelled with 3H-noradrenaline [51-41-2] were studied.In this article, certain chemicals are used. Some of their cas registry numbers are 51-41-2 and 15237-44-2 Preincubation with 3 .mu.M phenoxybenzamine-HCl [63-92-3] during 30 min increased 3-fold the tritium overflow during stimulation. Phentolamine-HCl [73-05-2] and phenoxybenzamine were nearly equipotent in reducing the vascular response to stimulation. In contrast, phentolamine was less potent than phenoxybenzamine in increasing the 3H-noradrenaline overflow elicited by stimulation. The results obtained with phentolamine are interpreted in terms of a different potency of phentolamine to produce blockade of prejunctional and postjunctional .alpha.-adrenoceptors in the rat portal vein. ATP Na salt [15237-44-2] inhibited by 70% the tritium overflow induced by stimulation. The potency of ATP in inhibiting the overflow increased when the prejunctional .alpha.-adrenoceptors were blocked. The purine compds. ATP, ADP Na salt [20398-34-9], and AMP Na salt [13474-03-8] and adenosine [58-61-7] were roughly equipotent in inhibiting stimulation-induced tritium overflow. The tritium released by stimulation decreased when uptake and metab. of adenosine were inhibited. Under physiol. conditions, a prejunctional purinergic inhibition of noradrenaline release might be involved in an endogenously mediated neg. feed-back regulatory mechanism. It is possible that the purinergic inhibition of the noradrenaline liberation elicited by stimulation plays a physiol. role in tissues with both purinergic and adrenergic innervation. .

ADP as one of the possible regulators of restoration processes in a cell and organism after irradiation

ADP as one of the possible regulators of restoration processes in a cell and organism after irradiation. Kozyreva, E. V.; Eliseenko, N. N.; Yashkin, P. N.; Tikhomirova, M. V. (USSR). Radiobiologiya, 17(5), 733-8 (Russian) 1977. CODEN: RADOA8. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 8 ADP Na salt (I Na salt) [20398-34-9] (175 mg/kg) administered i.p. or i.m. to rats 15 min before or 15 min after g-irradn. (750-900 R) increased survival to 47 and 34%, resp., in comparison with 9% in untreated, irradiated animals. When I was given both before and after irradn. survival was 72%. Expts. on model systems (fibroblast cells, liver mitochondria) indicated that the main mechanisms of the protective effect of I were activation of respiration and energy metab. and a simultaneous decrease in membrane permeability and deceleration of cell division.