Detail of "20408-97-3"

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CAS Number:
20408-97-3
Name:
D-Glucose, 5-thio-
Superlist Name:
5-Thio-D-glucose
Molecular Structure:
Formula:
C6H12 O5 S
Molecular Weight:
196.24
Synonyms:
5-Thio-D-glucose;5-Thioglucose; NSC 204984; Thioglucose
EINECS:
243-798-8
Density:
1.503 g/cm³
Melting Point:
135-138 °C(lit.)
Boiling Point:
463.3 °C at 760 mmHg
Flash Point:
234 °C
Safety:
Mildly toxic by intraperitoneal route. Mutation data reported. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of SO_x. Details

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The effect of gold compounds on human neutrophil myeloperoxidase: The effect of gold compounds on human neutrophil myeloperoxidase. Matheson, N. R.; Travis, J. (Dep. Biochem., Univ. Georgia, Athens, GA 30602, USA). Bioinorg. Chem. Gold Coord. Compd., Proc. Symp., Meeting Date 1981, 58-66. Edited by: Sutton, Blaine M.; Franz, Robert G. Smith Kline and French Lab.: Philadelphia, Pa. (English) 1983. CODEN: 52LMAY. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacology) Several compds. including Au antiarthritics and related structures were tested as inhibitors of the myeloperoxidase (MPO) [9003-99-0] system of human neutrophils; phosphine Au thiolates were the most effective. Structure-activity studies indicated that the SH group in the mol. was essential for MPO inhibitory activity. Of the compds. tested, the first 4 most effective were SKF-D-100336 (I) [83533-66-8], SKF-D-40079 [83678-72-2], SKF-58889 [51365-22-1], and auranofin [34031-32-8], all contg. Au. Au, however, was apparently not essential although it improved the effectiveness of compds. contg. it such as aurothioglucose [12192-57-3] and aurothiomalate [12244-57-4], compared to identical compds. lacking it such as 5-thio-D-glucose [20408-97-3] and thiomalate [70-49-5]. Inhibition of the MPO system may be one of several mechanisms whereby Au-contg. antiarthritic drugs produce their therapeutic benefit.

Effects of 5-thioglucose on external pancreatic secretion in the rat: Effects of 5-thioglucose on external pancreatic secretion in the rat. Comparison with 2-deoxy-D-glucose. Appia, F.; De la Tour, J.; Chariot, J.; Roze, C. (Fac. Med. X.-Bichat., Paris F-75018, Fr.). Gastroenterol. Clin. Biol., 8(10), 746-8 (French) 1984. CODEN: GCBIDC. ISSN: 0399-8320. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The efficacy of 5-thioglucose [20408-97-3] on pancreatic juice secretion (Na+ as a measure of vol., bicarbonate, and total protein) in rats was similar to that of 2-deoxyglucose [154-17-6], while the potency of thioglucose was greater than that of deoxyglucose. The ED50's for the 2 drugs were 25 and 60 mg/kg, resp.