Reference

Chemical models for toxic metabolites of bromobenzene derivatives

Chemical models for toxic metabolites of bromobenzene derivatives. Relative toxicity toward isolated hepatocytes. Gottschall, David W.; Harder, Raymond R.; Wiley, Robert A.; Hanzlik, Robert P. (Dep. Med. Chem., Univ. Kansas, Lawrence, KS 66045-2500, USA). 92836-13-0 which is the cas registry number of some chemical is mentioned. Toxicology, 31(3-4), 251-9 (English) 1984. CODEN: TXCYAC. ISSN: 0300-483X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The toxicity toward isolated rat hepatocytes of a series of cyclohexene and cyclohexadiene derivs. contg. epoxide and(or) a,b-unsatd. nitrile functional groups was detd. Simple epoxides and unsatd. nitriles were much less toxic than bromobenzene [108-86-1] itself, even if both groups were present in the same mol. However, a,b-unsatd. epoxides were 2-3 times more toxic than bromobenzene, and 310 times more toxic than their satd. analogs, which is consistent with their relatively greater chem. reactivity. It is unlikely that Michael acceptor metabolites account for the increased toxicity of o-bromobenzonitrile [2042-37-7] relative to bromobenzene. .

Separation of monosubstituted benzonitriles by gas-liquid chromatography

Separation of monosubstituted benzonitriles by gas-liquid chromatography. Habboush, Albertine E.; Najm, A. B. Kassim (Coll. Sci., Univ. Baghdad, Baghdad, Iraq). J. Chromatogr., 130, 161-8 (English) 1977. 2042-37-7 and 6952-59-6 which are cas registry numbers are also used here. CODEN: JOCRAM. DOCUMENT TYPE: Journal CA Section: 80 (Organic Analytical Chemistry) The forces influencing the sepn. order of monosubstituted benzonitriles on 1,2,3-tris-(2-cyanoethoxypropane), poly(propylene glycol), dinonyl phthalate, tritolyl phosphate, 2,4,7-trinitrofluorenone, silicone oil, and silicone gum rubber are discussed. Specific retention vols., heats of soln., electron polarizabilities and dipole moments were calcd. 1,2,3-Tris-(2-cyanoethoxypropane) was selective for the quant. sepn. of the isomers studied, followed by dinonyl phthalate, poly(propylene glycol), and tritolyl phosphate. .