Reference

Optimized process for synthesis of novel anti-influenza drug: Oseltamivir

Optimized process for synthesis of novel anti-influenza drug: Oseltamivir. 204255-04-9 and 204255-11-8 are also occured in this study. Gong, Xiao-ming; Xu, Ji-yang; Ding, Yu-lin (Department of Biochemistry, China Pharmaceutical University, Nanjing 210009, Peop. Rep. China). Zhongguo Xinyao Zazhi, 12(6), 454-456 (Chinese) 2003 Zhongguo Xinyao Zazhishe. CODEN: ZXZHA6. ISSN: 1003-3734. DOCUMENT TYPE: Journal CA Section: 33 (Carbohydrates) Title compd. was stereoselectively synthesized from (-)-quinic acid in twelve steps. The product structure was verified by FT-IR, 1H NMR and MS. The process provides mild reaction condition, lower cost, and higher yield. .

Efficacy of oseltamivir phosphate to horses inoculated with equine influenza A virus

All Rights Reserved. Efficacy of oseltamivir phosphate to horses inoculated with equine influenza A virus. Yamanaka, Takashi; Tsujimura, Koji; Kondo, Takashi; Hobo, Seiji; Matsumura, Tomio (Epizootic Research Center, Equine Research Institute, Japan Racing Association 1400-4 Shiba, Shimotsuke, Tochigi 329-0412, Japan). Journal of Veterinary Medical Science, 68(9), 923-928 (English) 2006 Japanese Society of Veterinary Science. CODEN: JVMSEQ. ISSN: 0916-7250. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) We investigated the efficacy of the oral administration of oseltamivir phosphate (OP) in horses exptl. infected with equine influenza A virus (H3N8). Nine horses were divided into three horses each of control, treatment and prophylaxis groups. An administration protocol for the treatment group (2 mg/kg of body wt., twice a day for five days) was started immediately after the onset of pyrexia (above 38.9°C). An administration protocol for the prophylaxis group (2 mg/kg of body wt., once a day for five days) was started on a day before viral inoculation.Several reagents such as 204255-11-8 is used here. In the treatment group, periods of virus excretion (mean days ± std. deviation, 2.3 ± 0.6) and pyrexia (2.0 ± 0.0) were apparently shorter than those of the control group (6.0 ± 0.0 and 8.0 ± 1.0, resp.). In the prophylaxis group, although virus excretion and pyrexia were not prevented, the periods of virus excretion (5.0 ± 0.0) and pyrexia (4.7 ± 1.5) were shorter than those of the control group. Moreover, in the treatment and prophylaxis groups, bacterial counts of Streptococcus equi subsp. zooepidemicus known as the common pathogen of secondary bacterial pneumonia in bronchoalveolar lavage fluids collected seven days after inoculation were significantly fewer than that of the control group. The results indicated that the oral administration of OP to horses affected with equine influenza would contribute to reduce the magnitude of virus excretion, pyrexia and consequent secondary bacterial pneumonia. .