Detail of "20438-03-3"

Reference

Negation of trypanocidal drug cures by polyamines

Bacchi, C. J.; Nathan, H. C.; Hutner, S. H.; Duch, D. S.; Nichol, C. A. (Haskins Lab., Pace Univ., New York, NY 10038, USA). Curr. Chemother. Infect. Dis., Proc. Int. Congr. Chemother., 11th, Meeting Date 1979, Volume 2, 1119-21. Edited by: Nelson, John D.; Grassi, Carlo. Am. Soc. Microbiol.: Washington, D. C. (English) 1980. CODEN: 43MKAT. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacodynamics) Amicarbalide [3459-96-9], imidocarb [27885-92-3], antrycide [3270-78-8], isometamidium [20438-03-3], pentamidine [100-33-4], or prothidium [14222-46-9] administered to mice infected with trypanosomes cured the infection at a dose of 1-25 mg/kg/day, but simultaneous administration of spermidine [124-20-9] at 300 mg/kg or spermine [71-44-3] at 100 mg/kg negated cures with almost all drugs. Negation of cures was independent of the route of administration.

Drug-resistant Leptomonas: cross-resistance in trypanocide-resistant clones

Bacchi, C. J.; Lambros, C.; Ellenbogen, B. B.; Penkovsky, L. N.; Sullivan, W.; Eyinna, E. E.; Hutner, S. H. (Haskins Lab., Pace Univ., New York, N. Y., USA). Antimicrob. Agents Chemother., 8(6), 688-92 (English) 1975. CODEN: AMACCQ. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) A Leptomonas of insect origin was highly susceptible to several std. trypanocides and leishmanicides in vitro. Resistance was induced to some of these drugs and clones were isolated from each strain. Cross-resistance patterns of the clones were derived for diamidines, Antrycide (quinapyramine) [20493-41-8], acriflavin [8048-52-0], phenanthridines, and other drugs active against trypanosomes and leishmanias. Clones tested included 2 each that were resistant to acriflavin, Antrycide, Berenil (diminazene aceturate) [908-54-3] and pentamidine [100-33-4] and 1 that was resistant to stilbamidine [122-06-5]. Appreciable cross-resistance was evident for all clones. Differences were obsd. between clones from the same parent strain. Collateral susceptibility towards isometamidium [20438-03-3] and oxophenarsine [306-12-7] was detected in most clone-derived populations. In clones passaged without drug to test for drug fastness, acriflavin and pentamidine clones lost resistance within 10 transfers, whereas Berenil and Antrycide clones retained considerable resistance after 20-30 subcultures without drug. Considerations of differences in life cycles suggest that the clone collection may be useful in screening for agents effective against leishmanias and stercorarian trypanosomes rather than against salivary trypanosomes.