Reference

N-Heterocyclic compounds as radioprotectors

N-Heterocyclic compounds as radioprotectors. 1. 2-Pyridinemethanethiol, 2-pyrazinemethanethiol and related compounds. Barnes, John H.; Fatome, Marc; Esslemont, George F.; Jones, Christopher E. L. (Dep. Chem. Metall., R. Mil. Coll.Several reagents with their cas registry numbers 625-57-0 and 31640-94-5 are used here. Sci., Shrivenham/Wiltshire SN6 8LA, UK). Eur. J. Med. Chem. - Chim. Ther., 18(6), 515-19 (English) 1983. CODEN: EJMCA5. ISSN: 0009-4374. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 8, 28, 29 Pyridines I [n = 0, 1; R = H, P(O)(ONa)2, CONH2, CSNEt2] and II (m = 0, 1) were prepd., and they showed radioprotective activity. 2-(Chloromethyl)pyridine hydrochloride was treated with tri-Na thiophosphate, and the pH was adjusted to 9 to give I [n = 0, R = P(O)(ONa)2]. Also prepd. was bis(pyrazinylmethyl) disulfide. .

Thioether coordinated metalloenediynes: Syntheses, structures and thermal reactivity comparison

Thioether coordinated metalloenediynes: Syntheses, structures and thermal reactivity comparison. Bhattacharyya, Sibaprasad; Pink, Maren; Huffman, John C.; Zaleski, Jeffrey M. 2044-73-7 are also occured in this study. (Department of Chemistry and Molecular Structure Center, Indiana University, Bloomington, IN 47405, USA). Polyhedron, 25(2), 550-558 (English) 2006 Elsevier B.V. CODEN: PLYHDE. ISSN: 0277-5387. DOCUMENT TYPE: Journal CA Section: 78 (Inorganic Chemicals and Reactions) Section cross-reference(s): 27, 75 Two novel, thioether contg. benzannulated enediyne ligands, 1,2-bis(3-(quinolin-8-ylsulfanyl)prop-1-ynyl)benzene (1), and 1,2-bis(3-(pyridin-2-ylmethylsulfanyl)prop-1-ynyl)benzene (2) were synthesized and characterized along with their corresponding Cu(I), Ag(I), Cu(II), and Pd(II) metalloenediyne complexes (3-10). Single crystal x-ray structures of the d10 and d8 N2S2 complexes show thioether coordination leading to distorted tetrahedral and trans square planar geometries about the metal centers, resp. Based on their x-ray structures, all complexes are expected to exhibit high Bergman cyclization temps. (>200°), and indeed this is the case for the Cu(I) and Ag(I) complexes (211-218°). In contrast, the corresponding divalent, tetragonal and trans square planar complexes of Cu(II) and Pd(II) exhibit more facile reactivity and lower solid state Bergman cyclization temps. (186-190°) which more closely resemble values expected for cis-complexes. The unusual order in the thermal reactivities of these constructs can be attributed to a previously evaluated mechanism by which weak thioether coordination permits an elevated temp. trans-to-cis geometric rearrangement prior to Bergman cyclization. .