CAS No.205110-48-1,Cethromycin Suppliers

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Basic Information

Molecular Structure:
CAS No.:	205110-48-1
Name:	Cethromycin
Article Data:	1

Formula:	C₄₂H₅₉N₃O₁₀
Molecular Weight:	765.945
Synonyms:	Cethromycin;ABT 773;Restanza;
Density:	1.22g/cm³
Melting Point:	211-213°
Boiling Point:	927.1°Cat760mmHg
Flash Point:	514.5°C
PSA:	162.82000
LogP:	5.43850

Synthetic route

: C40H72N2O13

: 205110-48-1
10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-3a,7,9,11,13,15-hexamethyl-11-(3-quinolin-3-yl-allyloxy)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1.1: sodium hydrogensulfite; formic acid / water; ethanol / 2.5 h / 86 °C 2.1: dmap / dichloromethane / 3 h / 20 °C 3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 3.2: 28 h / -40 - 20 °C / Inert atmosphere 4.1: ammonium hydroxide / tetrahydrofuran; acetonitrile / 192 h / 20 °C / Inert atmosphere 5.1: hydrogenchloride / water; ethanol / 22 h 6.1: N-chloro-succinimide; dimethylsulfide / dichloromethane / 0.5 h / -10 - -5 °C / Inert atmosphere 6.2: 1 h / 10 °C / Inert atmosphere 7.1: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 97 h / 50 - 90 °C / Inert atmosphere 8.1: methanol / Reflux View Scheme

Yield

Multi-step reaction with 8 steps
1.1: sodium hydrogensulfite; formic acid / water; ethanol / 2.5 h / 86 °C
2.1: dmap / dichloromethane / 3 h / 20 °C
3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
3.2: 28 h / -40 - 20 °C / Inert atmosphere
4.1: ammonium hydroxide / tetrahydrofuran; acetonitrile / 192 h / 20 °C / Inert atmosphere
5.1: hydrogenchloride / water; ethanol / 22 h
6.1: N-chloro-succinimide; dimethylsulfide / dichloromethane / 0.5 h / -10 - -5 °C / Inert atmosphere
6.2: 1 h / 10 °C / Inert atmosphere
7.1: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 97 h / 50 - 90 °C / Inert atmosphere
8.1: methanol / Reflux
View Scheme

: 198557-85-6
acetic acid 2-[4-(5-acetoxy-4-methoxy-4,6-dimethyl-tetrahydro-pyran-2-yloxy)-7-allyloxy-14-ethyl-12,13-dihydroxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-oxacyclotetradec-6-yloxy]-4-dimethylamino-6-methyl-tetrahydro-pyran-3-yl ester

: 205110-48-1
10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-3a,7,9,11,13,15-hexamethyl-11-(3-quinolin-3-yl-allyloxy)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 1.2: 28 h / -40 - 20 °C / Inert atmosphere 2.1: ammonium hydroxide / tetrahydrofuran; acetonitrile / 192 h / 20 °C / Inert atmosphere 3.1: hydrogenchloride / water; ethanol / 22 h 4.1: N-chloro-succinimide; dimethylsulfide / dichloromethane / 0.5 h / -10 - -5 °C / Inert atmosphere 4.2: 1 h / 10 °C / Inert atmosphere 5.1: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 97 h / 50 - 90 °C / Inert atmosphere 6.1: methanol / Reflux View Scheme

Yield

Multi-step reaction with 6 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
1.2: 28 h / -40 - 20 °C / Inert atmosphere
2.1: ammonium hydroxide / tetrahydrofuran; acetonitrile / 192 h / 20 °C / Inert atmosphere
3.1: hydrogenchloride / water; ethanol / 22 h
4.1: N-chloro-succinimide; dimethylsulfide / dichloromethane / 0.5 h / -10 - -5 °C / Inert atmosphere
4.2: 1 h / 10 °C / Inert atmosphere
5.1: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 97 h / 50 - 90 °C / Inert atmosphere
6.1: methanol / Reflux
View Scheme

: C48H75N3O15

: 205110-48-1
10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-3a,7,9,11,13,15-hexamethyl-11-(3-quinolin-3-yl-allyloxy)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: ammonium hydroxide / tetrahydrofuran; acetonitrile / 192 h / 20 °C / Inert atmosphere 2.1: hydrogenchloride / water; ethanol / 22 h 3.1: N-chloro-succinimide; dimethylsulfide / dichloromethane / 0.5 h / -10 - -5 °C / Inert atmosphere 3.2: 1 h / 10 °C / Inert atmosphere 4.1: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 97 h / 50 - 90 °C / Inert atmosphere 5.1: methanol / Reflux View Scheme

Yield

Multi-step reaction with 5 steps
1.1: ammonium hydroxide / tetrahydrofuran; acetonitrile / 192 h / 20 °C / Inert atmosphere
2.1: hydrogenchloride / water; ethanol / 22 h
3.1: N-chloro-succinimide; dimethylsulfide / dichloromethane / 0.5 h / -10 - -5 °C / Inert atmosphere
3.2: 1 h / 10 °C / Inert atmosphere
4.1: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 97 h / 50 - 90 °C / Inert atmosphere
5.1: methanol / Reflux
View Scheme

: 198557-87-8
2',4"-O-diacetyl-6-O-allyl-11,12-cyclocarbamate erythromycin A

: 205110-48-1
10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-3a,7,9,11,13,15-hexamethyl-11-(3-quinolin-3-yl-allyloxy)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: hydrogenchloride / water; ethanol / 22 h 2.1: N-chloro-succinimide; dimethylsulfide / dichloromethane / 0.5 h / -10 - -5 °C / Inert atmosphere 2.2: 1 h / 10 °C / Inert atmosphere 3.1: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 97 h / 50 - 90 °C / Inert atmosphere 4.1: methanol / Reflux View Scheme

: 205110-77-6
acetic acid 2-(11-allyloxy-4-ethyl-8-hydroxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy)-4-dimethylamino-6-methyl-tetrahydro-pyran-3-yl ester

: 205110-48-1
10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-3a,7,9,11,13,15-hexamethyl-11-(3-quinolin-3-yl-allyloxy)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: N-chloro-succinimide; dimethylsulfide / dichloromethane / 0.5 h / -10 - -5 °C / Inert atmosphere 1.2: 1 h / 10 °C / Inert atmosphere 2.1: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 97 h / 50 - 90 °C / Inert atmosphere 3.1: methanol / Reflux View Scheme

: 205110-78-7
acetic acid 2-(11-allyloxy-4-ethyl-3a,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxo-tetradecahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecen-10-yloxy)-4-dimethylamino-6-methyl-tetrahydro-pyran-3-yl ester

: 205110-48-1
10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-3a,7,9,11,13,15-hexamethyl-11-(3-quinolin-3-yl-allyloxy)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 97 h / 50 - 90 °C / Inert atmosphere 2: methanol / Reflux View Scheme

: C44H61N3O11

: 205110-48-1
10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-3a,7,9,11,13,15-hexamethyl-11-(3-quinolin-3-yl-allyloxy)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone

Conditions

Conditions	Yield
With methanol Reflux;	32.95 g

: 198482-51-8
6-O-allylerythromycin A

: 205110-48-1
10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-3a,7,9,11,13,15-hexamethyl-11-(3-quinolin-3-yl-allyloxy)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1.1: dmap / dichloromethane / 3 h / 20 °C 2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 2.2: 28 h / -40 - 20 °C / Inert atmosphere 3.1: ammonium hydroxide / tetrahydrofuran; acetonitrile / 192 h / 20 °C / Inert atmosphere 4.1: hydrogenchloride / water; ethanol / 22 h 5.1: N-chloro-succinimide; dimethylsulfide / dichloromethane / 0.5 h / -10 - -5 °C / Inert atmosphere 5.2: 1 h / 10 °C / Inert atmosphere 6.1: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 97 h / 50 - 90 °C / Inert atmosphere 7.1: methanol / Reflux View Scheme

Yield

Multi-step reaction with 7 steps
1.1: dmap / dichloromethane / 3 h / 20 °C
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
2.2: 28 h / -40 - 20 °C / Inert atmosphere
3.1: ammonium hydroxide / tetrahydrofuran; acetonitrile / 192 h / 20 °C / Inert atmosphere
4.1: hydrogenchloride / water; ethanol / 22 h
5.1: N-chloro-succinimide; dimethylsulfide / dichloromethane / 0.5 h / -10 - -5 °C / Inert atmosphere
5.2: 1 h / 10 °C / Inert atmosphere
6.1: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 97 h / 50 - 90 °C / Inert atmosphere
7.1: methanol / Reflux
View Scheme

: C55H104N2O14Si2

: 205110-48-1
10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-3a,7,9,11,13,15-hexamethyl-11-(3-quinolin-3-yl-allyloxy)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone

Conditions

Conditions	Yield
Multi-step reaction with 9 steps 1.1: acetic acid / acetonitrile; water / 20 °C 2.1: sodium hydrogensulfite; formic acid / water; ethanol / 2.5 h / 86 °C 3.1: dmap / dichloromethane / 3 h / 20 °C 4.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 4.2: 28 h / -40 - 20 °C / Inert atmosphere 5.1: ammonium hydroxide / tetrahydrofuran; acetonitrile / 192 h / 20 °C / Inert atmosphere 6.1: hydrogenchloride / water; ethanol / 22 h 7.1: N-chloro-succinimide; dimethylsulfide / dichloromethane / 0.5 h / -10 - -5 °C / Inert atmosphere 7.2: 1 h / 10 °C / Inert atmosphere 8.1: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 97 h / 50 - 90 °C / Inert atmosphere 9.1: methanol / Reflux View Scheme

Yield

Multi-step reaction with 9 steps
1.1: acetic acid / acetonitrile; water / 20 °C
2.1: sodium hydrogensulfite; formic acid / water; ethanol / 2.5 h / 86 °C
3.1: dmap / dichloromethane / 3 h / 20 °C
4.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
4.2: 28 h / -40 - 20 °C / Inert atmosphere
5.1: ammonium hydroxide / tetrahydrofuran; acetonitrile / 192 h / 20 °C / Inert atmosphere
6.1: hydrogenchloride / water; ethanol / 22 h
7.1: N-chloro-succinimide; dimethylsulfide / dichloromethane / 0.5 h / -10 - -5 °C / Inert atmosphere
7.2: 1 h / 10 °C / Inert atmosphere
8.1: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 97 h / 50 - 90 °C / Inert atmosphere
9.1: methanol / Reflux
View Scheme

: 2',4"-bis-O-trimethylsilylerythromycin A 9-O-(1-isopropoxycyclohexyl)oxime

: 205110-48-1
10-(4-dimethylamino-3-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-4-ethyl-3a,7,9,11,13,15-hexamethyl-11-(3-quinolin-3-yl-allyloxy)-octahydro-3,5-dioxa-1-aza-cyclopentacyclotetradecene-2,6,8,14-tetraone

Conditions

Conditions	Yield
Multi-step reaction with 10 steps 1.1: potassium tert-butylate / dimethyl sulfoxide; tetrahydrofuran / 4 h / 0 °C 2.1: acetic acid / acetonitrile; water / 20 °C 3.1: sodium hydrogensulfite; formic acid / water; ethanol / 2.5 h / 86 °C 4.1: dmap / dichloromethane / 3 h / 20 °C 5.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -40 °C / Inert atmosphere 5.2: 28 h / -40 - 20 °C / Inert atmosphere 6.1: ammonium hydroxide / tetrahydrofuran; acetonitrile / 192 h / 20 °C / Inert atmosphere 7.1: hydrogenchloride / water; ethanol / 22 h 8.1: N-chloro-succinimide; dimethylsulfide / dichloromethane / 0.5 h / -10 - -5 °C / Inert atmosphere 8.2: 1 h / 10 °C / Inert atmosphere 9.1: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 97 h / 50 - 90 °C / Inert atmosphere 10.1: methanol / Reflux View Scheme

Yield

Multi-step reaction with 10 steps
1.1: potassium tert-butylate / dimethyl sulfoxide; tetrahydrofuran / 4 h / 0 °C
2.1: acetic acid / acetonitrile; water / 20 °C
3.1: sodium hydrogensulfite; formic acid / water; ethanol / 2.5 h / 86 °C
4.1: dmap / dichloromethane / 3 h / 20 °C
5.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -40 °C / Inert atmosphere
5.2: 28 h / -40 - 20 °C / Inert atmosphere
6.1: ammonium hydroxide / tetrahydrofuran; acetonitrile / 192 h / 20 °C / Inert atmosphere
7.1: hydrogenchloride / water; ethanol / 22 h
8.1: N-chloro-succinimide; dimethylsulfide / dichloromethane / 0.5 h / -10 - -5 °C / Inert atmosphere
8.2: 1 h / 10 °C / Inert atmosphere
9.1: triethylamine; palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 97 h / 50 - 90 °C / Inert atmosphere
10.1: methanol / Reflux
View Scheme

Casno:
205110-48-1
CETHROMYCIN CAS：205110-48-1
Min.Order: 1 Kilogram
FOB Price: USD $ 40.0-60.0
Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be
Our company specializes in processing and selling chemical raw materials, chemical th Asia, Europe, America, Africa and other more than 20 countries and regions. ? Companies adheri
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Casno:
205110-48-1
Cethromycin
Min.Order: 10 Gram
FOB Price: USD $ 0.0-0.0
Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
TaiChem was established in 2015 and registered in China medical city - Taizhou, Jiangsu Province. The company has about 1800 square meters of class A plant facility. TaiChem focuse
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Cethromycin
Min.Order: 10 Gram
FOB Price: USD $ 0.0-0.0
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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205110-48-1
Cethromycin
Min.Order: 1 Kilogram
FOB Price: USD $ 2.0-2.0
Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
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205110-48-1
99% up by HPLC CETHROMYCIN 205110-48-1
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Cethromycin
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CETHROMYCINAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express
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205110-48-1
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205110-48-1
Cethromycin
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