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Detail of "20537-88-6"

  • CAS Number:
  • 20537-88-6
  • Name:

  • Amifostine

  • Molecular Structure:
  • Formula:
  • C5H15N2O3PS
  • Molecular Weight:
  • 214.25
  • Deleted CAS:
  • 63717-27-1|53028-04-9
  • Synonyms:
  • WR 2721;2-(3-aminopropylamino)ethylsulfanylphosphonic acid;Gammaphos;Aminopropylaminoethyl thiophosphate;Ethanethiol,2-[(3-aminopropyl)amino]-,dihydrogen phosphate (ester);Ethiofos;S-(2-(3-Aminopropylamino)ethyl) phosphorothioate;S-[2-[(3-Aminopropyl)amino]ethyl] dihydrogen phosphorothioate;AU-95722;Phosphorothioic acid, S-[2-[ (3-aminopropyl)amino]ethyl]ester;YM 08310;WR 2721C;Ethanethiol, S-[ (3-aminopropyl)amino]-, dihydrogen phosphate- (ester);SAPEP;2-(3-Aminopropylamino)ethyl thiophosphate;S-[2-(3-Aminopropylamino)ethyl] phosphorothioate;Ethanethiol, 2-[ (3-aminopropyl)amino]-, dihydrogen phosphate (ester);Aminopropyl aminoethylthiophosphate;S-2-(3-aminopropylamino)ethyl O,O-dihydrogen phosphorothioate;
  • Density:
  • 1.367 g/cm3
  • Melting Point:
  • 160.161 °C
  • Boiling Point:
  • 441.7 °C at 760 mmHg
  • Flash Point:
  • 220.9 °C
  • Solubility:
  • Soluble in water
  • Appearance:
  • White solid
  • Hazard Symbols:
  • HarmfulXn, IrritantXi
  • Risk Codes:
  • 22-36/37/38
  • Safety:
  • 26-36 Details
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CAS No.20537-88-6 AmifostineCompetitive Product

Name: Amifostine Synonyms：Ethiofos; 2-(3-Aminopropyl)aminoethyl phosphorothioate; Phosphorothioic acid S-(2-((3-aminopropyl)amino)ethyl) ester Molecular Formula：C5H15N2O3PS Molecular Weight: 214.22 CAS NO.: 20537-88-6

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CAS No.20537-88-6 Amifostine

Name: Ethyol (Amifostine) Synonyms: 2-(3-Aminopropyl)aminoethyl phosphorothioate CAS：20537-88-6 Formula (Hill Notation): C5H15N2O3PS Molecular Weight: 214.22 Function and Usage： Ethyol is MedImmune's chemoprotective agent used to reduce toxicities associated with radio/che

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Reference

Toxicity studies on the radioprotective agent WR-2721 in CDF1 mice and beagle dogs
Toxicity studies on the radioprotective agent WR-2721 in CDF1 mice and beagle dogs. Palmer, Thomas E.; Glaza, Steven M.; Dickie, Bruce C.; Weltman, Robert H.; Greenspun, Katherine S. (Dep. Pathol., Hazelton Lab. America, Inc., Madison, WI 53704, USA). Toxicol. Pathol., 13(1), 58-65 (English) 1985. CODEN: TOPADD. ISSN: 0192-6233. DOCUMENT TYPE: Journal CA Section: 8 (Radiation Biochemistry) Section cross-reference(s): 4 WR-2721 [20537-88-6] was administered i.v. to CDF1 mice and beagle dogs. Single dose lethality studies in mice showed the av. 0.1 of the LD, the median LD, and the 0.9 of the LD to be 508, 589, and 682 mg/kg, resp. The LD for female mice was lower than that for males. The 0.1 LD in mice was slightly toxic to dogs; 0.1 of that dose was nontoxic. The LD for dogs was higher than that for mice. Clin. sins of toxicosis in the single-dose mouse toxicity study were evident in the 1st wk following treatment and declined during the recovery period; signs of toxicosis were transient in dogs. Acute drug-induced pathol. changes included elevated blood urea N and serum glutamic-oxalacetic transaminase levels, lymphoid necrosis, and renal tubular degeneration in mice. These changes were evident in the 1st wk following treatment, but had dissipated by study termination. Generalized vascular changes and renal tubular degeneration occurred in treated dogs that had died or were killed moribund 7 days postinjection. These findings indicate sex-dependent and interspecies variation in the toxicity of WR-2721 with acute, but reversible, pathol. changes.
WR-2721 inhibits parathyroid adenylate cyclase
WR-2721 inhibits parathyroid adenylate cyclase. Weaver, Mark E.; Morrissey, Jeremiah; McConkey, Charles, Jr.; Goldfarb, Stanley; Slatopolsky, Eduardo; Martin, Kevin J. (Sch. Med., Washington Univ., St. Louis, MO 63110, USA). Am. J. Physiol., 252(2, Pt.There are some reagents with their cas registry numbers 9002-64-6 and 9012-42-4 are used in this study. 1), E197-E201 (English) 1987. CODEN: AJPHAP. ISSN: 0002-9513. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 8 The effects of WR-2721 [20537-88-6], a chemo- and radioprotectant on cAMP [60-92-4] prodn. in dispersed bovine parathyroid cells were studied. With parathyroid cells incubated at 0.5 mM Ca2+, addn. of WR-2721 at 0.02-2.0 mM resulted in a progressive decrease in intracellular cAMP (42-50%, resp.). In plasma membranes of bovine parathyroid cells a concn.-dependent decrease in adenylate cyclase [9012-42-4] activity was noted. Inhibition of the cyclase was seen over a wide range of Mg2+ concns. (2.5-40 mM). WR-2721 inhibited both basal and stimulated adenylate cyclase. The data suggest that WR-2721 inhibits the activity of parathyroid adenylate cyclase. This may explain the effect of WR-2721 on the secretion of parathyroid hormone [9002-64-6]. .
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