Reference

Pharmaceuticals containing sesquiterpene lactones in extracts from Tanacetum parthenium

Pharmaceuticals containing sesquiterpene lactones in extracts from Tanacetum parthenium. Johnson, Edward Stewart; Hylands, Peter John; Hylands, Deborah Margaret (UK ). Eur. Pat. Appl. EP 98041 A2 11 Jan 1984,93 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: IC: C07D493-04; C07D493-14; C07D519-00; C07D307-93; A61K031-365. ICI: C07D493-04, C07D307-00, C07D303-00; C07D493-14, C07D307-00, C07D303-00; C07D519-00, C07D493-00. 90052-50-9 and 90052-51-0 are cas registry numbers. These chemicals are also mentioned in this article. APPLICATION: EP 83-302790 17 May 1983. PRIORITY: GB 82-14572 19 May 1982; GB 82-27062 22 Sep 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1, 11, 30 A sesquiterpene lactone-contg. ext. for treatment of migraine, asthma, or arthritic conditions is obtained by extn. of T. parthenium (feverfew) with org. solvents or an oil. Chrysanthemonin (I) [90052-51-0], partholide (II) [90052-50-9], chrysanthemolide (III) [90052-49-6], chrysartemin A (IV) [24959-84-0], and parthenolide (V) [20554-84-1] were isolated from these exts. VI [90052-52-1] was obtained by hydrolysis of I. T. parthenium Leaves were extd. with light petroleum ether and the ext. purified by column chromatog. The leaves were also extd. with CHCl3 after petroleum ether extn. and this fraction purified by column chromatog. Fractions were further purified by column chromatog. and TLC to sep. the compd. The spasmolytic activity of the exts. was demonstrated on guinea pig ileum. Powd. feverfew leaf 10.0 and soybean oil 100.0 kg were mixed and allowed to stand 14 days and the mixt. stabilized by lecithin 2.2, hydrogenated fats 30.0, and beeswax 10.0 kg. The mixt. was encapsulated into capsules contg. a 25 mg dose of dried leaf. .

Cytotoxic agents from Michelia champaca and Talauma ovata: parthenolide and costunolide

Cytotoxic agents from Michelia champaca and Talauma ovata: parthenolide and costunolide. Hoffmann, Joseph J.; Torrance, Sterling J.; Wiedhopf, Richard M.; Cole, Jack R. (Coll. Pharm., Univ. Arizona, Tucson, Ariz., USA). J. Pharm. Sci., 66(6), 883-4 (English) 1977. CODEN: JPMSAE. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 11 The ethanol ext. of M. champaca and the petroleum ether ext. of T. ovata showed activity toward the human epidermoid carcinoma of the nasopharynx test system. The active constituents were sesquiterpene lactones, identified as parthenolide (I) [20554-84-1] and costunolide (II) [553-21-9]. Their identities were proven by elemental anal., PMR, IR, and mass spectral data, m.p. and mixed m.p. detns., and comparisons with authentic samples and spectra.