Reference

Effects of benzimidazole anthelmintics on the survival and migratory behavior of Toxocara canis larvae in the mouse

Effects of benzimidazole anthelmintics on the survival and migratory behavior of Toxocara canis larvae in the mouse. Abdel-Hameed, Ahmed Awad (Dep. Trop. Med., Tulane Univ., New Orleans, LA 70112, USA). Am. J. Vet. Res., 45(7), 1430-3 (English) 1984. CODEN: AJVRAH. ISSN: 0002-9645. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Nine benzimidazole anthelmintics (thiabendazole [148-79-8], mebendazole [31431-39-7], fenbendazole [43210-67-9], cambendazole [26097-80-3], flubendazole [31430-15-6], albendazole [54965-21-8], parbendazole [14255-87-9], oxibendazole [20559-55-1], and oxfendazole [53716-50-0]) were tested for their larvicidal effects and capabilities to inhibit migration of larval T. canis in mice. The drugs were administered in medicated diets contg. 0.1% (wt./wt.) of the pure compds. (130 to 160 mg/kg each day), starting 24 h after oral inoculation with 500 infective eggs. In mice killed after 8 days of treatment, all of the compds. except thiabendazole produced significant arrest of the migrating larvae in the liver. In mice given the normal diet for 2 wk after termination of treatment with the different drugs, the percentages of larvae that remained in the liver showed wide variation. Significant larvicidal effects were obsd. only in mice treated with albendazole, oxfendazole, and cambendazole.

Separation of benzimidazole anthelmintics by high-pressure liquid chromatography

Separation of benzimidazole anthelmintics by high-pressure liquid chromatography. Mourot, D.; Boisseau, J.; Gayot, G. (Lab. Natl. Med. Vet., Minist. Agric., Fougeres, Fr.). Anal. Chim. Acta, 99(2), 371-4 (English) 1978. CODEN: ACACAM. ISSN: 0003-2670. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Anthelmintic benzimidazoles, i.e., thiabendazole (I) [148-79-8], cambendazole [26097-80-3], parbendazole [14255-87-9], fenbendazole [43210-67-9], mebendazole [31431-39-7], and oxibendazole [20559-55-1] were sepd. by high-pressure liq. chromatog. using Lichrosorb RP8 column and reversed-phase gradient elution with the solvent MeCN-1% H2SO4. For these compds. Lichrosorb NH2 column with isocratic elution with solvent CH2Cl2-iso-PrOH ()-MeCN () was recommended. However, the last 2 compds. could not be sepd. by this procedure.