Detail of "2062-84-2"

Reference

Evidence for the existence of regulatory DA receptors in the substantia nigra

Evidence for the existence of regulatory DA receptors in the substantia nigra. Di Chiara, G.; Mereu, G. P.; Vargiu, L.; Porceddu, M. L.; Mulas, A.; Trabucchi, M.; Spano, P. F. (Inst. Pharmacol., Univ. Cagliari, Cagliari, Italy). Adv. Biochem. Psychopharmacol., 16(Nonstriatal Dopaminergic Neurons), 477-81 (English) 1977. CODEN: ABPYBL. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 13 The hypomotility caused by low doses of apomorphine [58-00-4] (0.02-0.2 mg/kg, s.c.) was prevented by pimozide [2062-78-4] (0.3 mg/kg, i.p.), benzperidol [2062-84-2] (0.05 mg/kg), droperidol [548-73-2] (0.05 mg/kg), or sulpiride [15676-16-1] (10 mg/kg). Pimozide also reversed the decrease of brain dihydroxyacetic acid (DOPAC) [563-96-2] levels (a measure of dopamine [51-61-6] metab.) caused by apomorphine. Thus, apomorphine appears to cause hypomotility by stimulating some autoregulatory dopamine receptors. A dopamine-sensitive adenylate cyclase [9012-42-4] was found in the ssubstantia nigra which was present even after 6-hydroxydopamine treatment, indicating that dopamine receptors are present, but are located on cells other than dopamianergic neurons. In addn., benzperidol injected into the substantia nigra caused contralateral turning behavior and increased striatal DOPAC ipsilaterally, indicating that it relieved nigral dopaminergic neurons from tonic inhibition influenced by dopamine. Thus, a tonic inhibitory activity on dopamine neurons is exerted by dopamaine released onto dopamine receptors located in the substantia nigra. In addn., apomorphine seems to inhibit locomotor behavior by stimulation of striatal dopamine receptors.

Spectrofluorometry of butyrophenones

Spectrofluorometry of butyrophenones. Baeyens, W. (Lab. Farm. Chem. Ontleding Geneesmiddelen, Rijksuniv. Gent, Ghent, Belg.). Pharm. Weekbl., 112(29), 681-91 (Dutch) 1977. CODEN: PHWEAW. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Neuroleptic butyrophenones (I) are detd. These substances emit fluorescent light on exposure to UV radiation. The qual. and quant. aspects of the native fluorescence of the butyrophenones depend on the solvent. Benperidol [2062-84-2], droperidol [548-73-2], azaperone [1649-18-9], and fluanisone [1480-19-9] exhibit a distinct signal, caused by the heterocyclic substitution of the .gamma.-aminobutyric acid chain. Qual. as well as quant. estms. were worked out, the latter requiring preliminary removal of interfering substances that absorb UV radiation. Haloperidol [52-86-8], bromoperidol [10457-90-6], trifluperidol [749-13-3], and pipamperone [1893-33-0] exhibit a rather weak signal.