Reference

Studies on the evaluation of drugs in sino-Japanese medicine

Studies on the evaluation of drugs in sino-Japanese medicine. 3. Determination of saikosaponins in Saikokeishi-to preparations. Ogawa, Kiyoshi; Katsuda, Yukie; Kitayama, Nobuaki; Tachi, Yukio; Taru, Atsubumi (Dep. Food and Drug, Ishikawa Res. Lab. Public Health Environ. Nobuaki, Ishikawaken, Japan). Ishikawa-ken Eisei Kogai Kenkyusho Nenpo, 20, 215-22 (Japanese) 1983. CODEN: IEKNE7. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Saikosaponin a [20736-09-8], d [20874-52-6], and c [20736-08-7] were extd. from the oriental drugs by using 2% KOH-MeOH soln. and converted to the dienes by treatment with 2% HCl-50% MeOH at 25° and quant. detd. by high-performance liq. chromatog. The degrdn. products, saikosaponin b1 [58558-08-0] and b2 [58316-41-9] were also identified.

Chronic effects of ginseng saponin, glycyrrhizin and flavin adenine dinucleotide on adrenal and thymus weight in normal and dexamethasone-treated rats

Chronic effects of ginseng saponin, glycyrrhizin and flavin adenine dinucleotide on adrenal and thymus weight in normal and dexamethasone-treated rats. Hiai, Susumu; Sasayama, Yuichi; Ogura, Chitaru (Res. Inst. WAKAN-YAKU, Toyama Med. Pharm. Univ., Toyama 930-01, Japan). Chem. Pharm. Bull., 35(1), 241-8 (English) 1987. CODEN: CPBTAL. ISSN: 0009-2363. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 The effects of chronic treatment with ginseng saponin, saikosaponin, glycyrrhizin [1405-86-3] and FAD [146-14-5] on the adrenal and thymus wt., and the size of the adrenal cortex and medulla were detd. in intact or hypophysectomized rats. A high dose of ginseng saponin decreased the thymus wt., although ginseng saponin and a low dose of ACTH induced insignificant hypertrophy of the adrenals. Ginseng saponin evoked an increase in the relative thickness of the adrenal cortex. Saikosaponin d [20874-52-6] increased the area of the adrenal cortex, but not that of the medulla, and induced adrenal hypertrophy and thymus atrophy, whereas saikosaponin c [20736-08-7] did not affect the wt. of either. A high dose of glycyrrhetinic acid [471-53-4], like ginseng saponin, induced thymus atrophy, but not adrenal hypertrophy. FAD evoked adrenal hypertrophy in dexamethasone-treated rats but not in control rats. In hypophysectomized rats these effects of ginseng saponin, saikosaponin d and FAD disappeared, while a low dose of dexamethasone or ACTH induced thymus atrophy or adrenal hypertrophy, resp. These compds.In this experiment, several chemicals are used like 471-53-4 and 20874-52-6 , thus, act on the hypothalamic-pituitary system to produce the obsd. effects. .