Reference

Comparison of induction characteristics of four intravenous anesthetic agents

Comparison of induction characteristics of four intravenous anesthetic agents. McCollum, J.Several substances are used for example 76-75-5 and 33125-97-2 which are their cas registry numbers. S. C.; Dundee, J. W. (Dep. Anaesthet., Queen's Univ. Belfast, Belfast BT9 7BL, UK). Anaesthesia, 41(10), 995-1000 (English) 1986. CODEN: ANASAB. ISSN: 0003-2409. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The induction characteristics of i.v. thiopentone [76-75-5], etomidate [33125-97-2], and methohexitone [151-83-7] were compared to those of propofol (2,6 di-iso-Pr phenol) [2078-54-8] in unpremedicated patients. Propofol (2.5 mg/kg) caused more hypotension, excitatory side effects and pain after injection into the dorsum of the hand than thiopentone (5 mg/kg). However, with regard to the latter 2 sequelae, etomidate (0.3 mg/kg) and methohexitone (1.5 mg/kg) caused similar or more frequent upset. Propofol (2.0 mg/kg) was equipotent with thiopentone (4.0 mg/kg) in terms of successful induction of anesthesia. Dose-related hypotension may contraindicate the use of propofol in hypovolemic or elderly patients. .

I

I.C.I. 35868, a new intravenous induction agent. Kay, B.; Rolly, G. (Dep. Anesthesiol., Akad. Ziekenhuis, Ghent, Belg.). Acta Anaesthesiol. Belg., 28(4), 303-16 (English) 1977. CODEN: AABEAJ. ISSN: 0001-5164. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) I.C.I. 35868 (I) [2078-54-8] appeared to be a clin. effective i.v. induction agent, 1 mg/kg probably being the most appropriate dose. I produced similar respiratory and cardiovascular depression to methohexitone, but appeared to be more rapidly metabolized and excreted. Pain after injection was the only side-effect seen with I.