Reference

Basic substituted phenylacetonitriles

Basic substituted phenylacetonitriles. Dengel, Ferdinand (Knoll A.-G. Chemische Fabriken, Ger.). Ger. Offen. DE 2631222 19 Jan 1978, 13 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07C121-66. APPLICATION: DE 76-2631222 12 Jul 1976. DOCUMENT TYPE: Patent CA Section: 25 (Noncondensed Aromatic Compounds) Nine title compds. I (R, R2, R3, R4, R5 = H, halo, alkoxy, R1 = halo, alkoxy, R6 = alkyl) and (or) their HCl and bioxalate salts were prepd. Thus, 3,4-(MeO)2C6H3CH(CHMe2)CN was condensed with ClCH2CH2CH(OEt)2 in refluxing PhMe with addn. of NaNH2 over 3 h to give 84.3% 3,4-(MeO)2C6H3C(CHMe2)(CN)(CH2)2CH(OEt)2, which was ~ quant. hydrolyzed with aq. (CO2H)2 and the resulting aldehyde condensed with 3,4-(MeO2C6H3CH2CH2NH2 in EtOH during hydrogenation over Pd/C to give 92% II, characterized as the HCl salt. 20850-49-1 is the cas registry number. This chemical is also mentioned in this article. .