Reference

Comparative effect of glucagon, dibutyryl cyclic AMP, and epinephrine on the desaturation and elongation of linoleic acid by rat liver microsomes

Comparative effect of glucagon, dibutyryl cyclic AMP, and epinephrine on the desaturation and elongation of linoleic acid by rat liver microsomes. De Gomez Dumm, Irma N. T.; De Alaniz, Maria J. T.; Brenner, Rofolfo R. (Fac. Cienc. Med., Univ. Nac. La Plata, La Plata, Argent.). Lipids, 11(12), 833-6 (English) 1976. CODEN: LPDSAP. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) The effect on in vivo administration of glucagon [9007-92-5], dibutyryl cyclic adenosine 3',5'-monophosphate Na salt [19436-29-4] and epinephrine [51-43-4] on the biosynthesis of polyunsatd. fatty acids by incubated rat liver microsomes under desatg. and elongating conditions was studied. Under desatg. conditions, linoleic acid [60-33-3] was converted to .gamma.-linolenic acid [506-26-3], whereas under elongating conditions it was converted to .omega.6 [2091-39-6]. Glucagon, dibutyryl cyclic AMP, and epinephrine decreased the oxidative desatn. of linoleic acid to .gamma.-linolenic acid while the elongating reaction was not modified in the exptl. conditions tested. The oxidative desatn.In this experiment, several chemicals are used like 9007-92-5 and 60-33-3 of linoleic acid to .gamma.-linolenic acid is apparently the main controllable step in the biosynthesis of polyunsatd. fatty acids of the linoleic acid family in the microsomes. .

Are long-chain polyunsaturated fatty acids necessary in the human diet?

Are long-chain polyunsaturated fatty acids necessary in the human diet?. Sanders, T. A. B.; Ellis, F. R.; Dickerson, J. W. T. (Dep. Pathol., Kingston Hosp., Kingston/Surrey, Engl.). Proc. Nutr. Soc., 35(3), 125A-127A (English) 1976. CODEN: PNUSA4. DOCUMENT TYPE: Journal CA Section: 18 (Animal Nutrition) Examn. of the fatty acids of plasma choline phosphoglycerides (CPG) and of lipids of erythrocytes of vegetarians, whose diet contains no long-chain polyunsatd. fatty acids (LCPFA, C20-22, with 2-6 double bonds) and comparison with proportions from omnivores indicated that LCPFA are not necessary, per se, in the human diet. In the plasma CPG, proportions of total PFA and short-chain PFA were greater in vegetarians than in omnivores, but proportions of LCPFA were the same. In erythrocyte lipids proportions of .omega.6 [2091-39-6], .omega.6 [506-32-1], and .omega.6 [28874-58-0] were greater and those of .omega.3 [1553-41-9], .omega.6 [2313-14-6], .omega.3 [2234-74-4], and .omega.3 [2091-24-9] were lower in vegetarians than in omnivores.