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20977-05-3

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Basic Information
CAS No.: 20977-05-3
Name: Escin, monosodium salt
Molecular Structure:
Molecular Structure of 20977-05-3 (Escin, monosodium salt)
Formula: C53H82O36S4
Molecular Weight: 0
Synonyms: Sodium escinate;Aescin sodium salt;Aescusan sodium salt;
EINECS: 244-133-4
Melting Point: 250-252 °C
Appearance: COA
PSA: 359.64000
LogP: -1.92040
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Chemistry

Product Name: Escin, sodium salt
Synonyms of Escin, sodium salt (CAS NO.20977-05-3): Sodium escin ; Sodium escinate
CAS NO: 20977-05-3
Molecular Structure: Unspecified

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 9130ug/kg (9.13mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
mouse LD50 intraperitoneal 8299ug/kg (8.299mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 114, 1974.
mouse LD50 intravenous 4730mg/kg (4730mg/kg)   Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 22, Pg. 87, 1987.
mouse LD50 oral 134mg/kg (134mg/kg)   Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 22, Pg. 87, 1987.
mouse LD50 subcutaneous 92530ug/kg (92.53mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 114, 1974.
rabbit LD50 intravenous 5mg/kg (5mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
Link to PubMed
rat LD50 intraperitoneal 9180ug/kg (9.18mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 114, 1974.
rat LD50 intravenous 8131ug/kg (8.131mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 114, 1974.
rat LD50 oral 400mg/kg (400mg/kg)   Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 22, Pg. 87, 1987.
rat LD50 subcutaneous 131mg/kg (131mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 114, 1974.

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Experimental teratogenic and reproductive effects. When Escin, sodium salt (CAS NO.20977-05-3) is heated to decomposition, it emits toxic fumes of Na2O. See also SAPONIN and ESCIN; α-ESCIN; β-ESCIN; ESCIN TRIETHANOLAMINE SALT.