Detail of "20994-83-6"

CAS Number:
20994-83-6
Name:
Caerulein, 4-desulfo-
Molecular Structure:
Formula:
C58H73 N13 O18 S
Molecular Weight:
1272.34
Synonyms:
Caerulein,4-de(hydrogen sulfate) (8CI); 4-Desulfocaerulein; Caerulein 1.1Y4 (Litoriacitropa); Desulfated caerulein; Desulfated ceruletide

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The effects of gastrin and gastrin analogs on pancreatic acinar cell membrane potential and resistance: The effects of gastrin and gastrin analogs on pancreatic acinar cell membrane potential and resistance. Iwatsuki, N.; Kato, K.; Nishiyama, A. (Sch. Med., Yamagata Univ., Yamagata, Japan). Br. J. Pharmacol., 60(1), 147-54 (English) 1977. CODEN: BJPCBM. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) Cholecystokinin-pancreozymin (I) [9011-97-6], gastrin [9002-76-0], caerulein [17650-98-5], and desulfated caerulein (II) [20994-83-6] stimulated mouse and rat pancreatic acinar cells, with immediate depolarization and a concommitant redn. in input resistance and time const. The depolarization was not abolished by atropine. The gastrin-type secretagog depolarization returned quickly to the resting level, but that evoked by the I-type group was long lasting. The time course and dose-response curve of II was identical with that of gastrin. The activity of gastrin was exerted by the C-terminal tetrapeptide, but caerulein activity depended on the C-terminal heptapeptide, esp. the sulfated tyrosyl residue at position 7. The equiv. sulfated tyrosyl residue in I was probably necessary for max. activity. The relative potencies were caerulein > I > gastrin. Synthetic gastrin was more effective than either tetra- or pentagastrin.

Regulation of the dissociation of [3H]-caerulein from its pancreatic receptors: evidence for negative cooperativity: Regulation of the dissociation of [3H]-caerulein from its pancreatic receptors: evidence for negative cooperativity. Deschodt-Lanckman, Monique; Svoboda, Michal; Camus, Jean C.; Robberecht, Patrick (Fac. Med., Univ. Libre Bruxelles, Brussels, Belg.). INSERM Symp., 3(Horm. Recept. Dig. Tract Physiol., Proc. Int. Symp., 1st), 325-6 (English) 1977. CODEN: INSSDM. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) The rate of dissocn. of 3H-labeled caerulein [17650-98-5] from pancreatic membrane receptors was accelerated in the presence of unlabeled caerulein. Similar effects were caused by pancreozymin C-terminal octapeptide [25126-32-3], BOC-(norleucine8)-(4-10)-caerulein [29129-57-5], desulfated caerulein [20994-83-6], and (11-17)heptagastrin I [30626-80-3]; with their efficiency being proportional to their binding affinities.