Detail of "21136-70-9"

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Teratological assessment of five oxidative hair dyes in the rat

Teratological assessment of five oxidative hair dyes in the rat. DiNardo, J. C.; Picciano, J. C.; Schnetzinger, R. W.; Morris, W. E.; Wolf, B. A. (Dep. Pharmacol. Toxicol., Revlon Res. Cent., Inc., Edison, NJ 08818, USA). Toxicol. Appl. Pharmacol., 78(1), 163-6 (English) 1985. CODEN: TXAPA9. ISSN: 0041-008X. DOCUMENT TYPE: Journal CA Section: 62 (Essential Oils and Cosmetics) The oxidative dyes, 4,4'-diaminodiphenylene sulfate [21136-70-9], N'-(2-hydroxyethyl)-4-nitro-o-phenylenediamine [96512-75-3], N,N-dimethyl-p-phenylenediamine [99-98-9], 2,3-dihydroxynaphthalene [92-44-4], and resorcinol [108-46-3], were evaluated for teratogenic potential. Dyes were administered by gavage to pregnant Sprague-Dawley rats on gestation days 6 through 15 at 12.5-500 mg/kg. No overt signs of toxicity were obsd. during the treatment period. A significant redn. in mean maternal wt. gain was noted during the treatment period at the high dose for 4,4'-diaminodiphenylene sulfate, N'-(2-hydroxyethyl)-4-nitro-o-phenylenediamine, and 2,3-dihydroxynaphthalene. The high dose for N,N-dimethyl-p-phenylenediamine and resorcinol, which exceeded a 100-fold exaggeration of human exposure, did not produce a significant redn. in maternal wt. gain. An evaluation of fetal external, visceral, and skeletal anomalies revealed no statistically significant differences between dye-treated and vehicle control groups. Administration of 100,000 units of Vitamin A, the pos. control, on Day 9 of gestation resulted in a significant increase in abnormal fetuses.

Preparation of benzidine by rearrangement of hydrazobenzene

Preparation of benzidine by rearrangement of hydrazobenzene. Mester, Tamas; Kortvelyessi, Gyula; Halmos, Jozsef; Hutak, Antal; Weichinger, Laszlo (Szerves Vegyipari Fejleszto Kozo Vallalat, Hung.). Hung. Teljes HU 56535 A2 30 Sep 1991, 13 pp. (Hungary). CODEN: HUXXBU. CLASS: ICM: C07C211-50. APPLICATION: HU 90-1314 6 Mar 1990. DOCUMENT TYPE: Patent CA Section: 25 (Benzene, Its Derivatives, and Condensed Benzenoid Compounds) Benzidine is prepd. by rearrangement of hydrazobenzene, using H2SO4 in a toluene-water system. 21136-70-9 and 92-87-5 which are cas registry numbers are also used here. A mixt. of 1250 g 20% H2SO4 and 400 mL toluene was treated with 180 g hydrazobenzene (prepd. by redn. of nitrobenzene). The benzidine sulfate formed was sepd. by filtration, treated with water and toluene at 90°, followed by addn. of Na2CO3 to pH 7 to give benzidine (99.5% purity) by cooling. The method is environmentally safe. .