Reference

Radioprotective properties of hypoxia during the administration of antihypoxic drugs

Radioprotective properties of hypoxia during the administration of antihypoxic drugs. Titov, B. A.In this study， 11006-56-7 and 7782-44-7 are also used.; Zherebchenko, P. G.; Znamenskii, V. V.; Terekhov, A. V. (USSR). Radiobiologiya, 17(1), 63-6 (Russian) 1977. CODEN: RADOA8. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 8 In expts. on mice, rats, and dogs the radioprotective properties of hypoxia were not affected by the antihypoxic agents, gutimine [2114-02-5] and (or) vitamin B15 [12767-61-2], when based on postirradn. survival rate. However, based on the no. of karyocytes in bone marrow, the radioprotective effect of hypoxia was decreased by the antihypoxic agents. .

Effect of gutimine on the brain electroencephalogram and blood supply in cats with intracerebral hemorrhage

Effect of gutimine on the brain electroencephalogram and blood supply in cats with intracerebral hemorrhage. Plotnikov, M. B.; Korobova, Z. V.; Chernysheva, G. A. (Tomsk. Med. Inst., Tomsk, USSR). Farmakol. Toksikol. (Moscow), 47(6), 36-9 (Russian) 1984. CODEN: FATOAO. ISSN: 0014-8318. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In conscious cats 1-2 days after intracerebral hemorrhage (administration of 2 mL autogenous blood into the internal capsule of the right hemisphere), i.v. injection of 50 mg/kg gutimine [2114-02-5] led to an increase in the brain blood supply. The increased local blood flow was recorded in the cortex, thalamus of the affected hemisphere, and particularly in the midbrain reticular formation. Expts. in vitro demonstrated that gutimine had a direct dilatatory action on isolated strips of cat internal maxillary and artery, this action being detd. by inhibition of the metab. and intracellular Ca2+.