Detail of "2138-22-9"

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Substituent effect on kinetics and mechanism of the oxidation of 1,2-benzenediols with thallium(III) in aqueous acid perchlorate media

Substituent effect on kinetics and mechanism of the oxidation of 1,2-benzenediols with thallium(III) in aqueous acid perchlorate media. Giraudi, G.In this study， 2138-22-9 and 120-80-9 are also used.; Baiocchi, C. (Italy). Atti Accad. Sci. Torino, Cl. Sci. Fis., Mat. Nat., 109(5-6), 603-10 (English) 1975. CODEN: AATFAA. DOCUMENT TYPE: Journal CA Section: 22 (Physical Organic Chemistry) The kinetics of the oxidn. of 4-RC6H3(OH)2-1,2 (R = H, Me, Cl) by Tl(ClO4)3 in 0.12-0.70 M HClO4 are 1st order each in H+ and substrate. An inner-sphere mechanism was proposed. .

Differences in urinary monochlorobenzene metabolites between rats and humans

Differences in urinary monochlorobenzene metabolites between rats and humans. Ogata, M.Some chemicals with cas registry numbers like 21462-48-6 and 2138-22-9 are also used.; Shimada, Y. (Med. Sch., Okayama Univ., Okayama 700, Japan). Int. Arch. Occup. Environ. Health, 53(1), 51-7 (English) 1983. CODEN: IAEHDW. ISSN: 0340-0131. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The high-performance liq. chromatog. method for the detn. of S-(p-chlorobenzene)mercapturic acid (I) [21462-48-6] and 4-chlorocatechol [2138-22-9] conjugates is described. For detn. of urinary mercapturic acid, the benzene ext. from urine was injected into a liq. chromatograph and for detn. of urinary 4-chlorocatechol conjugates, hydrolyzate was dissolved in MeOH. The MeOH soln. contg. 4-chlorocatechol was injected into a liq. chromatograph. Differences in urinary excretion of monochlorobenzene between rats and humans were studied. Monochlorobenzene was administered to rats i.p., and to humans orally or by inhalation. Urinary p-chlorophenylmercapturic acid, and 4-chlorocatechol after hydrolysis of its conjugate, were measured. The amt. of total metabolites is proportional to the doses administered to rats, rabbits, and mice by i.p. injection. The ratio of urinary mercapturic acid to 4-chlorocatechol is in the order of rats, mice, and rabbits by i.p. injection, and rats and human beings by oral administration. The excretion of p-chlorophenylmercapturic acid was markedly less than 4-chlorocatechol in humans who received monochlorobenzene orally or by inhalation. Thus, the 4-chlorocatechol conjugate is a suitable index of metabolites in the urine of workers exposed to monochlorobenzene. .