CAS No.2140-76-3,2'-O-Methyluridine Suppliers

Detail of "2140-76-3"

CAS Number:

2140-76-3

Name:

2'-O-Methyluridine

Molecular Structure:

Formula:

C₁₀H₁₄N₂O₆

Molecular Weight:

258.23

Synonyms:

O(2)-Methyluridine;2-O-Methyluridine;Uridine, 2-O-methyl-;1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]pyrimidine-2,4-dione;

Density:

1.53 g/cm³

Hazard Symbols:

T+

Risk Codes:

26/27/28

Safety:

24/25 Details

Reference

Effect of a new fungicide (PNDP) on the minor nucleotide content of Fusarium oxysporum: Effect of a new fungicide (PNDP) on the minor nucleotide content of Fusarium oxysporum. Jakucs, Erzsebet; Racz, Ilona; Lasztity, D. (Dep. Microbiol., Eotvos Lorand Univ., Budapest H-1088, Hung.). Acta Microbiol. Hung., 31(1), 27-33 (English) 1984. CODEN: AMHUEF. DOCUMENT TYPE: Journal CA Section: 5 (Agrochemical Bioregulators) Fifteen minor nucleotides were identified in 18S rRNA from F. oxysporum grown for 8 days in aerated liq. culture. These were: 6-methyladenine [443-72-1], 1-methyladenine [5142-22-3], 2-methyladenine [1445-08-5], 2,6-dimethyladenine (m62 A) [90375-79-4], 1-methylguanosine [2140-65-0], 2-methylguanosine (m2G) [2140-77-4], 2,2-dimethylguanosine [2140-67-2], 3-methylcytidine (m3C) [2140-64-9], 2'-O-methylcytidine (CM) [2140-72-9], 5-methylcytidine (m5C) [2140-61-6], 3-methyluridine [2140-69-4], 2'-O-methyluridine [2140-76-3], 5-carboxymethyluridine [20964-06-1], ribothymidine [1463-10-1] and pseudouridine (Y) [1445-07-4]. M62A, m2G, m3C, Cm, m5C, and Y were not detected in 25S rRNA. Treatment with PNDP [87810-43-3] decreased the content of nucleotides of F. oxysporum. 5-Methoxycarbonylmethyl-2-thiouridine [20299-15-4] was identified in RNA of the PNDP-treated fungus. Apparently, PNDP inhibited the synthesis of RNA-modifying enzymes of the fungus, similarly to cycloheximide.

Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage: Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage. Lapeyre, Bruno; Purushothaman, Suresh K. (Centre de Recherche de Biochimie Macromoleculaire, Montpellier 34293, Fr.). Molecular Cell, 16(4), 663-669 (English) 2004 Cell Press. CODEN: MOCEFL. ISSN: 1097-2765. DOCUMENT TYPE: Journal CA Section: 7 (Enzymes) RRNA mols. undergo extensive posttranscriptional modification, predominantly via 2'-O-ribose methylation and pseudouridine formation, both of which are guided by the numerous small nucleolar RNAs in eukaryotes.Several substances with their cas registry numbers 2140-76-3 and 86352-24-1 may be metioned in this study. Here, we describe an exception to this rule. The essential yeast nucleolar protein Spb1p is a site-specific rRNA methyltransferase modifying the universally conserved G2922 that is located within the A loop of the catalytic center of the ribosome. The equivalent position in bacteria is the docking site for aminoacyl-tRNA, and it is crit. for translation. In sharp contrast to other 2'-O-methylriboses that are formed on the primary transcript, Gm2922 appears at a late processing stage, during the maturation of the 27S pre-rRNA. Thus, eukaryotes have maintained a site-specific enzyme to catalyze the methylation of a nucleotide that plays a crucial role in ribosome biogenesis and translation. .

Detail of "2140-76-3"

2'-O-Methyluridine

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CAS No.2140-76-3 2'-O-Methyluridine

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CAS No.2140-76-3 2'-O-Methyluridine

CAS No.2140-76-3 2'-O-Methyluridine

CAS No.2140-76-3 2'-O-Methyluridine

CAS No.2140-76-3 2'-O-Methyluridine

CAS No.2140-76-3 2'-O-Methyluridine

Reference