Detail of "21411-53-0"

CAS Number:
21411-53-0
Name:
3H-21,18-Nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone,8,9,14,15,24,25-hexahydro-14-hydroxy-4,12-dimethyl-3-(1-methylethyl)-, (3R,4R,5E,10E,12E,14S)-
Molecular Structure:
Formula:
C28H35 N3 O7
Molecular Weight:
525.5934
Synonyms:
Mikamycin A(6CI,8CI); Ostreogrycin A (7CI); Virginiamycin M1; Antibiotic PA 114A;Antibiotic PA 114A1; Factor M; Factor M (antibiotic); NSC 244426; NSC 87432; PA114A; Pristinamycin II; Pristinamycin IIA; RP 12536; Staphylomycin M1;Streptogramin A; Vernamycin A;[3R-(3R*,4R*,5E,10E,12E,14S*)]-8,9,14,15,24,25-Hexahydro-14-hydroxy-4,12-dimethyl-3-(1-methylethyl)-3H-21,18-nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone
EINECS:
244-376-6
Density:
1.26 g/cm³
Boiling Point:
825.2 °C at 760 mmHg
Flash Point:
452.9 °C

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VIRGINIAMYCIN M3

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Preparation and properties of derivatives of virginiamycin S: Preparation and properties of derivatives of virginiamycin S. Janssen, G.; Anne, J.; Vanderhaeghe, H. (Rega Inst., Univ. 38188-91-9 and 62408-55-3 are cas registry numbers. These chemicals are also mentioned in this article. Leuven, Louvain, Belg.). J. Antibiot., 30(2), 141-5 (English) 1977. CODEN: JANTAJ. DOCUMENT TYPE: Journal CA Section: 16 (Fermentations) Redn. of virginiamycin S (I) [9040-14-6] with NaBH4 produces allo- (II) [42116-61-0] and normal-dihydrovirginiamycin S (III) [42116-62-1]. Redn. of the tosylhydrazone of virginiamycin S with Na cyanoborohydride affords deoxyvirginiamycin S (IV) [38188-91-9]. These compds. are less active than virginiamycin S. Like virginiamycin S they enhance the activity of virginiamycin M1 [21411-53-0]. .

Cooperative and antagonistic interactions of peptidyl-tRNA and antibiotics with bacterial ribosomes: Cooperative and antagonistic interactions of peptidyl-tRNA and antibiotics with bacterial ribosomes. Contreras, Antonio; Vazquez, David (Inst. Bioquim. Macromol., CSIC, Madrid, Spain). Eur. J. Biochem., 74(3), 539-47 (English) 1977. CODEN: EJBCAI. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) Section cross-reference(s): 6 Thiamphenicol [15318-45-3] and chloramphenicol [56-75-7] are good inhibitors of peptide bond formation in ribosomes and polysomes, their affinities for ribosomes being increased when peptidyl-tRNA was present on the P-site preceding the peptide bond formation. The binding of thiostrepton [1393-48-2] to ribosomes was unaffected by the attachment of mRNA, tRNA, or nascent peptides to either the A- or P-site. Lincomycin [154-21-2], erythromycin [114-07-8], streptogramin B [3131-03-1], and streptogramin A [21411-53-0] bound to ribosomes and polysomes totally free from nascent peptides, but they did not interact with ribosomes bearing nascent peptides in either the A- or P-site. Consequently, these latter antibiotics are not active on preformed polysomes.