Detail of "21461-84-7"

Reference

Preparation of amlodipine salts with furancarboxylic acid derivatives for dosage forms

Preparation of amlodipine salts with furancarboxylic acid derivatives for dosage forms. Cho, Seong-Hwan; Youn, Yong-Sik; Jung, Yun-Taek; Park, Choong-Sil; Lee, Hyuk-Koo; Lee, Kwang-Hyeg; Jeong, Eun-Ju; Kim, Young-Hoon; Jin, Hae-Tak; Cheon, Jun-Hee; Lee, Sung-Hak; Jung, Sung-Hak; Lim, Dong-Kwon; Yeon, Kyu-Jeong; Kim, Yun-Cheul; Park, Kyung-Mi; Kang, Hyun-Suk (CJ Corp., S. Korea). PCT Int. Appl. WO 2004011434 A1 5 Feb 2004, 22 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07D211-86. 652970-03-1 and 21461-84-7 are also in the experiment. APPLICATION: WO 2003-KR1525 30 Jul 2003. PRIORITY: KR 2002-44857 30 Jul 2002. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 27 Prepn. of amlodipine salts with tetrahydro-5-oxo-2-furancarboxylic acids (yield about 90%) and their physicochem. properties and pharmaceutical compns., such as capsules and tablets, for treatment of cardiac ischemia are described. .

Stereochemical research on drugs

Stereochemical research on drugs. Part 3. Asymmetrical transformation and chiroptic properties in the mefruside series. Pohl, H. Uwe; Wollweber, Hartmund (Forschungslab., Bayer A.-G.Chemicals with cas numbers 14796-41-9 and 21461-84-7 also play role., Uerdingen, Ger.). Eur. J. Med. Chem. - Chim. Ther., 11(2), 163-71 (German) 1976. CODEN: EJMCA5. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 22 Comparison of chiroptic data of (+)-tetrahydrofurancarboxylic acid I with the data of the enantiomers of II shows that the Cotton effect of the lactone chromophase of I is 1 magnitude larger than that of the CO2H group. Thus, it is possible to use the Cotton effect of I to det. the abs. configuration and confirm the earlier classification of Cervinka et al. (1968) that (+)-I has the (R)-configuration. The abs. configurations of the enantiomers of tetrahydrofurans II, III (R = H, Me) and of mefruside and its derivs. IV (R = Me, H, Z = H2; R = Me, Z = O) were detd. by comparison with (R)-I using asym. transformation and ORD curves. .