Reference

The effect of antimicrobial agents on leukocyte chemotaxis

The effect of antimicrobial agents on leukocyte chemotaxis. Esterly, Nancy B.; Furey, Nancy L.; Flanagan, Lillian E. (Dep. Pediatr., Michael Reese Hosp. Med. Cent., Chicago, Ill., USA). J. Invest. Dermatol., 70(1), 51-5 (English) 1978. CODEN: JIDEAE. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The effects of several chemotherapeutic agents on the chemotaxis of human leukocytes were studied in an in vitro system using a Sykes-Moore chamber and a double-filter technique. Chemotactic factor was generated by the interaction of normal human serum and zymosan. At concns. comparable to and below therapeutic blood levels, tetracycline-HCl (I-HCl) [64-75-5], erythromycin [114-07-8], and clindamycin-HCl [21462-39-5] were all inhibitory, causing marked suppression of leukocyte chemotaxis and slight redn. of random migration. Penicillin G Na [69-57-8], dapsone [80-08-0], and sulfapyridine [144-83-2] did not alter white cell motility at the concns. of drug tested. Thus, the capacity of some of these agents to inhibit leukocyte chemotaxis may account, in part, for their efficacy in inflammatory skin disease such as acne vulgaris.

Antibacterial activity of combinations of clindamycin and antifolate agents

Antibacterial activity of combinations of clindamycin and antifolate agents. Brumfitt, W.; Hamilton-Miller, J. M. T.; Grey, Daphne (Dep. Med. Microbiol., R. Free Hosp. Sch. Med., London, Engl.). Microbios Lett., 4(14), 95-8 (English) 1977. CODEN: MILEDM. ISSN: 0307-5494. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) The antibacterial activities of clindamycin-HCl (I-HCl) [21462-39-5] in combination with the folate antagonists trimethoprim lactate [23256-42-0] or sulfamethoxazole [723-46-6] were only additive, suggesting that I is not an antifolate agent. Thus, some other mechanism of action must be responsible for the therapeutic effects of I against malaria and toxoplasmosis, conditions known to be susceptible to treatment with antifolate compds. Inhibition of protein synthesis is the most likely explanation for the action of I, but other antibiotics which inhibit bacterial protein synthesis have generally shown little activity against malaria.