Detail of "2153-98-2"
- CAS Number:
- 2153-98-2
- Name:
Benzenemethanol, a-[(1S)-1-aminoethyl]-,hydrochloride (1:1), (aS)-
- Superlist Name:
- Norpseudoephedrine hydrochloride
- Molecular Structure:
![Molecular Structure of 2153-98-2 (Benzenemethanol, a-[(1S)-1-aminoethyl]-,hydrochloride (1:1), (aS)-)](http://www.lookchem.com/300w/2010/0620/2153-98-2.jpg)
- Formula:
- C9H13 N O . Cl H
- Molecular Weight:
- 187.69
- Synonyms:
- Benzenemethanol,a-(1-aminoethyl)-, hydrochloride,[S-(R*,R*)]-; Benzenemethanol, a-[(1S)-1-aminoethyl]-, hydrochloride, (aS)- (9CI); Norpseudoephedrine, hydrochloride(6CI,7CI); Norpseudoephedrine, hydrochloride, (+)- (8CI);(1S,2S)-(+)-Pseudonorephedrine hydrochloride; (S)-(+)-Norpseudoephedrinehydrochloride; Adiposetten; Amorphan; Cathine hydrochloride; Exponcit N;Fasupond; Fugoa; L-Norpseudoephedrine hydrochloride; Minusin;d-Norpseudoephedrine hydrochloride; threo-2-Amino-1-hydroxy-1-phenylpropanehydrochloride
- EINECS:
- 218-446-1
- Melting Point:
- 172-175 °C
- Solubility:
- H2O: ~20 mg/mL
- Appearance:
- solid ,white
- Hazard Symbols:
- Risk Codes:
- R22
- Safety:
- Poison by intraperitoneal, subcutaneous and intravenous routes. When heated to decomposition it emits very toxic fumes of HCl and NOx. Details
Benzenemethanol, a-[(1S)-1-aminoethyl]-,hydrochloride (1:1), (aS)-
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Reference
- Biopharmaceutical studies with D-norpseudoephedrine
- Biopharmaceutical studies with D-norpseudoephedrine. Part 2. Bioavailability of a depot preparation. Frosch, F. (Galenischen Lab., Firma E. Scheurich, Pharmwerk G.m.b.H., Appenweier, Ger.). Arzneim.-Forsch., 27(5), 1076-8 (German) 1977. CODEN: ARZNAD. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The bioavailability of D-norpseudoephedrine-HCl (I-HCl) [2153-98-2] in Fugoa depot dragees was 95% of that for I-HCl in hard gelatin capsules in normal subjects. The plasma I concn. showed a plateau lasting from 2 to 6 h after administration of the depot I-HCl prepn.
- Oxidative decomposition of phenylalkylamines and chromatographic identification of the resulting amine compounds
- Oxidative decomposition of phenylalkylamines and chromatographic identification of the resulting amine compounds. Part I. Oxo products of permanganate and ninhydrine oxidation. Brantner, Antal; Vamos, Jozsef; Gracza Lukacs, Maria (Gyogyszereszi Kem. Intez., Semmelweis Orvostud. Egy., Budapest, Hung.). Gyogyszereszet, 20(10), 369-76 (Hungarian) 1976. CODEN: GYOGAI. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Detn. of norpseudoephedrine-HCl [2153-98-2], ephedrine-HCl [50-98-6], methylephedrine-HCl [942-46-1], sympethamine [94-07-5], bamethan sulfate [5716-20-1], adrenaline [51-43-4], noradrenaline bitartrate [51-40-1], isoprenaline-HCl [51-30-9], corbadrine [829-74-3], methylprenaline [1212-03-9], amphetamine phosphate [139-10-6], pholedrine [370-14-9], and Visken [21870-06-4] by thin-layer chromatog. (silica gel plate 3:7 Et2O-petroleum ethe or Et2O-CCl4) is possible after the removal of arom. or aliph. aldehydes from the N-alkyl group, facilitated by oxidizing agents (e.g. 5% KMnO4 and ninhydrin buffered to pH 8). The aldehydes and ketones thus formed can be distd. from the reaction mixt., reacted with 2,4-dinitrophenylhydrazine and compared with authentic substances on the plate. The decompn. is also useful in structure detn. in the anal. of drugs. In drugs contg. 2 phenolic groups (adrenaline, noradrenaline, isoprenaline, and methylprenaline) the glycol-type decompn. is of secondary importance. The decompn. of the N-isopropyl group can go in 2 directions.