Reference

Mianserin hydrochloride: a novel antidepressant

Mianserin hydrochloride: a novel antidepressant. Coppen, Alec; Gupta, Ramesh; Montgomery, Stuart; Ghose, Karabi; Bailey, John; Burns, Bruce; De Ridder, J. J. (MRC Neuropsychiatry Lab., West Park Hosp., Epsom/Surrey, Engl.). Br. J. Psychiatry, 129(Oct.), 342-5 (English) 1976. CODEN: BJPYAJ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Mianserin-HCl (I) [21535-47-7], given at 20 mg 3 times a day to persons with primary depressive illness, had antidepressant effects which were comparable with those of amitriptyline. Side-effects such as a decrease in salivary secretion were more pronounced with amitriptyline than with I.

Psychomotor skills during acute and two-week treatment with mianserin (Org GB 94) and amitriptyline, and their combined effects with alcohol

Psychomotor skills during acute and two-week treatment with mianserin (Org GB 94) and amitriptyline, and their combined effects with alcohol. Seppala, T. (Dep. Pharmacol., Univ. Helsinki, Helsinki, Finland). Ann. Clin. Res., 9(2), 66-72 (English) 1977. CODEN: ACLRBL. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 4 Healthy volunteers took a placebo, 10 mg of mianserin-HCl (I)-HCl) [21535-47-7] and 25 mg of amitriptyline-HCl (II-HCl) [549-18-8] 3 times a day for 2 weeks each, in a double-blind cross-over manner. Several psychomotor tests were done on the first, 7th and 14th days of each period with EtOH [64-17-5] (0.5 g/kg) or a placebo drink. Co-ordinative and reactive skills and critical flicker frequency were affected by all the drug-drink combinations whereas attention was slightly impaired only after II alone or I together with alcohol. Drug actions and drug-alcohol interactions were most obvious on the 1st day but declined towards the end of the drug periods. After I the skills were impaired on the first day only, but after II up to the 7th day in most of the tests. Both drugs seemed to interact additively with alcohol. Impairment of flicker fusion by II + alcohol remained const. over the whole 2-week period.