Detail of "21561-99-9"

Reference

Interrelationship between tumorigenicity and the chemical nature of N-methyl-N'-aryl-N-nitrosoureas

Interrelationship between tumorigenicity and the chemical nature of N-methyl-N'-aryl-N-nitrosoureas. Yano, Kazuyuki; Katayama, Hiroo; Takemoto, Kazuo (Dep. Chem., Saitama Med. Sch., Iruma 350-04, Japan). Cancer Res., 44(3), 1027-30 (English) 1984. CODEN: CNREA8. ISSN: 0008-5472. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The tumorigenic activity of N-methyl-N'-aryl-N-nitrosoureas (I, R = OMe, Me, H, Cl, Ac, and NO2) on mouse skin was investigated in comparison with N-methyl-N-nitrosourea (MNU) [684-93-5]. The tumorigenic potency of I was less than MNU, although I were much stronger mutagens; and no correlations were found between the tumorigenicity of I and their mutagenicity. 21561-99-9 and 72586-67-5 are cas registry numbers of chemicals which are used as reagents here. The major tumors induced by I (R = MeO and Me), both of which have high lipophilicity, were sarcomas (fibrosarcomas and fibroanaplastic, anaplastic, and pleomorphic cell sarcomas) in contrast to the squamous cell carcinomas induced by MNU. Although the nitrosoureas were not administered intragastrically to the animals, squamous cell carcinomas were obsd. in the forestomachs of mice treated with I, but no tumors were produced in the stomachs by MNU. Adenocarcinomas were found in the lungs of mice treated with all the nitrosoureas. Hyperplastic nodules were obsd. in the livers of mice treated with I (R = Me and H), while cysts were found with Me derivs. .