Detail of "2166-31-6"

Reference

Synthesis and evaluation as PDE IV inhibitors of 4,5-hetero-condensed-6-phenyl-3(2H)-pyridazinones

Synthesis and evaluation as PDE IV inhibitors of 4,5-hetero-condensed-6-phenyl-3(2H)-pyridazinones. Dal Piaz, Virrorio; Giovannoni, Maria Paola; Castellana, Carla; Palacios, Jose Maria; Beleta, Jorge; Domenech, Teresa; Segarra, Victor (Departimento di Scienze Farmaceutiche, Florence 50121, Italy). Acta Pharmaceutica Hungarica, 66(Suppl.), S33-S34 (English) 1996 Ifjusagi Lap- es Konyvkiado Vallalat. CODEN: APHGAO. ISSN: 0001-6659.Several substances with their cas registry numbers 9036-21-9 and 2166-31-6 may be metioned in this study. DOCUMENT TYPE: Journal; General Review CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 7 A lecture with 9 refs. including discussion of the prepn. and pharmacol. of the title compds. .

Reaction between benzoylacrylic acid and hydrazines

Reaction between benzoylacrylic acid and hydrazines. Moreau, R. C.; Loiseau, P. (Fac. Pharm., Paris, Fr.). Ann. Pharm. Fr., 36(1-2), 67-75 (French) 1978. CODEN: APFRAD. ISSN: 0003-4509. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Treating PhCOCH:CHCO2H with hydrazine in acid medium gave 72% 6-phenyl-3-pyridazinol, whereas use of alk.Several substances are used for example 2166-31-6 which is its cas registry number. medium gave 30% 3-phenyl-2-pyrazoline-5-carboxylic acid. The same reaction with MeNHNH2 gave 1-methyl-3-phenyl-2-pyrazoline in both acid and alk. medium; excess MeNHNH2 gave hydrazide I. Treating PhCOCH:CHCO2H with PhNHNH2 in acid medium gave the hydrazone, whereas in alk. medium 1,3-diphenyl-2-pyrazoline-5-carboxylic acid was obtained. RR1NNH2 (RR1N = NMe2, morpholino) gave RR1NNHCH(CO2H)CH2COPh. .