Detail of "21757-82-4"

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The effects of the insecticide 2,2,2-trichloro-1-(3,4-dichlorophenyl)ethyl acetate on drug metabolism in the rat

The effects of the insecticide 2,2,2-trichloro-1-(3,4-dichlorophenyl)ethyl acetate on drug metabolism in the rat. Mantyla, Eero; Ahotupa, Markku; Hietanen, Eino; Vainio, Harri (Dep. Physiol., Univ. Turku, Turku, Finland). Toxicology, 27(3-4), 327-36 (English) 1983. CODEN: TXCYAC. ISSN: 0300-483X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The effects of 2,2,2-trichloro-1-(3,4-dichlorophenyl)ethyl acetate (Penfenate) [21757-82-4] on hepatic, renal, and small intestinal drug-metabolizing enzyme activities, hepatic GSH [70-18-8] content, and urinary excretion of thioethers were studied in the rat. A single i.p.There are some reagents with their cas registry numbers 9048-63-9 and 70-18-8 are used in this study. dose of Penfenate (500 mg/kg) decreased the body wt. of the animals in 1-3 days, increased hepatic protein content at 2 days, and increased urinary thioether excretion 12-24 h after the treatment. In the liver, a single i.p. dose (500 mg/kg) enhanced cytochrome P 450 [9035-51-2] content 1.7-fold, ethoxycoumarin O-deethylase [42613-26-3] activity 2.5-fold, 2,5-diphenyloxazole hydroxylase [70025-39-7] activity 1.6-fold, and epoxide hydrolase [9048-63-9] activity 2.5-fold in 3 days. The insecticide also enhanced glutathione S-transferase [50812-37-8] activity 1.4-fold and UDP-glucuronosyltransferase (4-methylumbelliferone) [9030-08-4] activity 2.3-fold in 3 days. No effects could be seen 2 wk after the treatment. Five consecutive daily doses (500 mg/kg) enhanced the drug-metabolizing enzyme activities and caused a 50% mortality. A dose of 100 mg/kg had only minor effects on hepatic drug-metabolizing enzyme activities. Renal and intestinal enzyme activities were only slightly affected by the administration of Penfenate. Thus, quite large doses of Penfenate are needed to bring about any significant effects and these effects are restricted mainly to the liver. However, the ability of Penfenate to change drug-metabolizing enzyme activities must be considered when evaluating the advantages and disadvantages of this insecticide as a substitute for DDT. .

Toxicity, distribution, and elimination of plifenate in white rats

Toxicity, distribution, and elimination of plifenate in white rats. Fytizas, Raymonde; Ioannou, A. (Lab. Control Toxicol. Pestic., Inst. Phytopathol. Benaki, Athens, Greece). Ann. Inst. Phytopathol. Benaki, 13(2), 168-77 (French) 1982. CODEN: APYBAQ. ISSN: 0365-5814. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) A single oral administration of 250 mg plifenate (I) [21757-82-4]/kg (a sublethal dose) resulted in translocation to adipose tissue, and esp. brain and testes of rats. The I levels reached max. within 24 h. Within 96 h after the administration, the I in the tissue decreased below the detection threshold. Repeated administration of 250 mg I/kg for 15 days caused no accumulation. Most tissues were cleared by I within 4 days of termination of the administration. Administration of 10-100 mg I/kg for a year resulted in a concn.-dependent accumulation (adipose tissue 6.00, liver 4.33, kidneys 1.51 mg/g for the 100 mg/kg dose). No toxic symptoms (liver or total wt. changes) followed the chronic administration of I.