Detail of "21849-70-7"

CAS Number:
21849-70-7
Name:
2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-
Molecular Structure:
Formula:
C15H12 O5
Molecular Weight:
272.25
Synonyms:
Chalcone,2',3,4,4'-tetrahydroxy- (7CI,8CI); 2',3,4,4'-Tetrahydroxychalcone;2',4',3,4-Tetrahydroxychalcone; 3,4,2',4'-Tetrahydroxychalcone; NSC 652892
Solubility:
DMSO: >50 mg/mL
Appearance:
Yellow Solid
Safety:
22-24/25 Details

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12-O-tetradecanoylphorbol 13-acetate-caused increase in vascular permeability in mouse skin (II): 12-O-tetradecanoylphorbol 13-acetate-caused increase in vascular permeability in mouse skin (II). Effects of caffeic acid derivatives, chalcone derivatives and calcium blockers on it. Nakadate, Teruo; Yamamoto, Satoshi; Aizu, Eriko; Kato, Ryuichi (Sch. Med., Keio Univ., Tokyo, Japan). Ensho, 4(4), 554-6 (Japanese) 1984. CODEN: ENSHEE. ISSN: 0389-4290. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) 3,4,2',4'-Tetrahydroxychalcone [21849-70-7], 3,4,2'-trihydroxychalcone [6272-43-1], isoliquiritigenin [961-29-5], 3,4-dihydroxychalcone [72704-76-8], Ca blockers (nifedipine [21829-25-4], verapamil [52-53-9], D 600 [16662-47-8]) and quercetin [117-39-5] inhibited TPA (I) [16561-29-8]-induced vascular permeability in mice, whereas caffeic acid [331-39-5] and chlorogenic acid [327-97-9] did not. Chalcone derivs. with the catechol group inhibited both lipoxygenase [9029-60-1] and cyclooxygenase [39391-18-9] in the skin whereas those without the catechol group inhibited cyclooxygenase but not lipoxygenase. Caffeic acid derivs. had no effect on both enzymes. Quercetin inhibited lipoxygenase but not cyclooxygenase.