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CAS No.: | 21948-70-9 |
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Name: | 2-(Methylthio)pyrazine |
Article Data: | 9 |
Molecular Structure: | |
Formula: | C5H6N2S |
Molecular Weight: | 126.182 |
Synonyms: | Pyrazine,(methylthio)- (6CI,7CI,8CI,9CI);(Methylthio)pyrazine;2-Methylmercaptopyrazine;Methyl pyrazinyl sulfide;Pyrazinyl methyl sulfide; |
EINECS: | 244-675-1 |
Density: | 1.19 g/cm3 |
Melting Point: | 44 °C |
Boiling Point: | 221.2 °C at 760 mmHg |
Flash Point: | 87.6 °C |
Hazard Symbols: | Xn |
Risk Codes: | 22-37/38-41 |
Safety: | 22-24/25-39-26 |
PSA: | 51.08000 |
LogP: | 1.19850 |
Conditions | Yield |
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In 1-methyl-pyrrolidin-2-one at 80℃; for 0.0138889h; microwave irradiation; | 88% |
In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere; | 49% |
Conditions | Yield |
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With 1,4-diaza-bicyclo[2.2.2]octane; fac-tris(2-phenylpyridinato-N,C2')iridium(III); dimethyl sulfoxide In acetonitrile at 20℃; for 24h; Irradiation; Sealed tube; chemoselective reaction; | 85% |
Conditions | Yield |
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In neat (no solvent) at 60℃; for 16h; Sealed tube; | 57% |
Conditions | Yield |
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With rat liver microsomes In phosphate buffer at 37℃; for 0.5h; pH=7.5; Enzyme kinetics; Methylation; Enzymatic reaction; |
Conditions | Yield |
---|---|
Stage #1: 2-chloropyrazin With potassium tert-butylate; thiourea In dimethyl sulfoxide for 3h; UV-irradiation; Stage #2: methyl iodide In water; dimethyl sulfoxide | A n/a B 83 % Chromat. |
Conditions | Yield |
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In acetonitrile at 20℃; for 0.0833333h; | 95% |
tributyl(4-chlorophenyl)stannane
2-(methylthio)pyrazine
2 (4-chlorophenyl)-pyrazine
Conditions | Yield |
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With trans benzyl(chloro)bis(triphenylphosphine)palladium(II); copper(I) 2-hydroxy-3-methylbenzoate In tetrahydrofuran at 50℃; | 92% |
trimethylsilyl cyanide
2-(methylthio)pyrazine
3-(methylthio)pyrazine-2-carbonitrile
Conditions | Yield |
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Stage #1: 2-(methylthio)pyrazine With trifluoromethylsulfonic anhydride In chloroform at 20℃; for 1h; Inert atmosphere; Sealed tube; Stage #2: trimethylsilyl cyanide In chloroform at 60℃; for 3h; Inert atmosphere; Sealed tube; Stage #3: With 4-methyl-morpholine In chloroform at 60℃; for 17h; Inert atmosphere; Sealed tube; | 92% |
Conditions | Yield |
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at 80℃; for 2h; | 90% |
Conditions | Yield |
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Stage #1: 2-(methylthio)pyrazine With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex In tetrahydrofuran at -20℃; for 4h; Inert atmosphere; Schlenk technique; Stage #2: zinc trimethylacetate In tetrahydrofuran at 0 - 25℃; for 0.25h; Inert atmosphere; Schlenk technique; | 89% |
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