Welcome to LookChem.com Sign In|Join Free

Home > Pharmaceutical > 219810 >

219810-59-0

Products Categories

Pharmaceutical (19)
Others (6)
Materials (2)
Organic Chemicals (1)

Basic Information

Molecular Structure:
CAS No.:	219810-59-0
Name:	NERAMEXANE
Article Data:	12

Formula:	C₁₁H₂₃N
Molecular Weight:	169.31
Synonyms:	1,3,3,5,5-pentamethylcyclohexylamine;1-amino-1,3,3,5,5-pentamethyl-cyclohexan;Neramexane;1-amino-1,3,3,5,5-pentamethylcyclohexane;1,3,3,5,5-Pentamethylcyclohexanamine;Neramexane [INN];MRZ 2-579;1,1,3,3,5-pentamethyl-cyclohexanamine;Cyclohexanamine,1,3,3,5,5-pentamethyl;
Density:	0.809g/cm³
Boiling Point:	195.5°Cat760mmHg
Flash Point:	39.7°C
PSA:	26.02000
LogP:	3.64040

Synthetic route

: 457068-92-7
Neramexane mesylate

: 219810-59-0
neramexane

Conditions	Yield
With sodium hydroxide In water at 20℃;	100%

: 316364-93-9
N-Chloroacetyl-1,3,3,5,5-pentamethylcyclohexanamine

: 219810-59-0
neramexane

Conditions	Yield
Stage #1: N-Chloroacetyl-1,3,3,5,5-pentamethylcyclohexanamine With hydrogenchloride; thiourea In water for 6h; Reflux; Stage #2: With sodium hydroxide In water pH=7;	89%
With acetic acid; thiourea In ethanol for 10h; Substitution; Heating;
Stage #1: N-Chloroacetyl-1,3,3,5,5-pentamethylcyclohexanamine With hydrogenchloride; thiourea In water for 6h; Reflux; Stage #2: With sodium hydroxide In water pH=7;
Stage #1: N-Chloroacetyl-1,3,3,5,5-pentamethylcyclohexanamine With hydrogenchloride; thiourea In water for 6h; Reflux; Stage #2: With sodium hydroxide In water pH=7; Product distribution / selectivity;

: 1-azido-1,3,3,5,5-pentamethyl-cyclohexane

: 219810-59-0
neramexane

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether at 20℃; for 5h; Reduction;

: 38490-33-4
1,3,3,5,5-pentamethylcyclohexanol

: 219810-59-0
neramexane

Conditions	Yield
Multi-step reaction with 2 steps 1: 86 percent / AcOH; H2SO4 / 5 h / 20 °C 2: thiourea; AcOH / ethanol / 10 h / Heating View Scheme
Multi-step reaction with 2 steps 1: 67 percent / HN3; TiCl4 / CHCl3 / 24 h / 20 °C 2: LiAlH4 / diethyl ether / 5 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1.1: sulfuric acid / acetic acid / 1 h / 5 - 10 °C 2.1: hydrogenchloride; thiourea / water / 6 h / Reflux 2.2: pH 7 View Scheme

: 14376-79-5
3,3,5,5-tetramethylcyclohexanone

: 219810-59-0
neramexane

Conditions	Yield
Multi-step reaction with 3 steps 1: 93 percent / diethyl ether / 1 h / 20 °C 2: 67 percent / HN3; TiCl4 / CHCl3 / 24 h / 20 °C 3: LiAlH4 / diethyl ether / 5 h / 20 °C View Scheme
Multi-step reaction with 3 steps 1.1: tetrahydrofuran / 5 - 15 °C 2.1: sulfuric acid / acetic acid / 1 h / 5 - 10 °C 3.1: hydrogenchloride; thiourea / water / 6 h / Reflux 3.2: pH 7 View Scheme
Multi-step reaction with 3 steps 1.1: tetrahydrofuran / 1 h / 5 - 15 °C 2.1: sulfuric acid / acetic acid / 1 h / 5 - 10 °C 3.1: hydrogenchloride; thiourea / water / 6 h / Reflux 3.2: pH 7 View Scheme

: 78-59-1
3,5,5-Trimethylcyclohex-2-en-1-one

: 219810-59-0
neramexane

Conditions	Yield
Multi-step reaction with 4 steps 1.1: copper(l) iodide; lithium chloride / tetrahydrofuran / 1 h / 5 - 15 °C 2.1: tetrahydrofuran / 5 - 15 °C 3.1: sulfuric acid / acetic acid / 1 h / 5 - 10 °C 4.1: hydrogenchloride; thiourea / water / 6 h / Reflux 4.2: pH 7 View Scheme
Multi-step reaction with 4 steps 1.1: copper(l) iodide; lithium chloride / tetrahydrofuran / 1 h / 5 - 15 °C 2.1: tetrahydrofuran / 1 h / 5 - 15 °C 3.1: sulfuric acid / acetic acid / 1 h / 5 - 10 °C 4.1: hydrogenchloride; thiourea / water / 6 h / Reflux 4.2: pH 7 View Scheme

: 457068-92-7
Neramexane mesylate

: 219810-59-0
neramexane

Conditions	Yield
With sodium hydroxide In water at 20℃;	100%

: 316364-93-9
N-Chloroacetyl-1,3,3,5,5-pentamethylcyclohexanamine

: 219810-59-0
neramexane

Conditions	Yield
Stage #1: N-Chloroacetyl-1,3,3,5,5-pentamethylcyclohexanamine With hydrogenchloride; thiourea In water for 6h; Reflux; Stage #2: With sodium hydroxide In water pH=7;	89%
With acetic acid; thiourea In ethanol for 10h; Substitution; Heating;
Stage #1: N-Chloroacetyl-1,3,3,5,5-pentamethylcyclohexanamine With hydrogenchloride; thiourea In water for 6h; Reflux; Stage #2: With sodium hydroxide In water pH=7;
Stage #1: N-Chloroacetyl-1,3,3,5,5-pentamethylcyclohexanamine With hydrogenchloride; thiourea In water for 6h; Reflux; Stage #2: With sodium hydroxide In water pH=7; Product distribution / selectivity;

: 1-azido-1,3,3,5,5-pentamethyl-cyclohexane

: 219810-59-0
neramexane

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether at 20℃; for 5h; Reduction;

: 38490-33-4
1,3,3,5,5-pentamethylcyclohexanol

: 219810-59-0
neramexane

Conditions	Yield
Multi-step reaction with 2 steps 1: 86 percent / AcOH; H2SO4 / 5 h / 20 °C 2: thiourea; AcOH / ethanol / 10 h / Heating View Scheme
Multi-step reaction with 2 steps 1: 67 percent / HN3; TiCl4 / CHCl3 / 24 h / 20 °C 2: LiAlH4 / diethyl ether / 5 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1.1: sulfuric acid / acetic acid / 1 h / 5 - 10 °C 2.1: hydrogenchloride; thiourea / water / 6 h / Reflux 2.2: pH 7 View Scheme

About us - Payment - Contact us - Links - Help Center - Disclaimer
SiteMap | Manufacturers | VIP Product | Suppliers | CAS | New CAS | Cas Database | Article Data | Chemical Catalog | Product Name

©2008 LookChem.com,License:ICP NO.:Zhejiang16009103 complaints:service@lookchem.com
[Hangzhou]86-571-87562588,87562561,87562573 Our Legal adviser: Lawyer