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| CAS No.: | 220000-87-3 |
|---|---|
| Name: | N-Methyl-4-chloropyridine-2-carboxamide |
| Article Data: | 105 |
| Molecular Structure: | |
|
|
|
| Formula: | C7H7ClN2O |
| Molecular Weight: | 170.598 |
| Synonyms: | 2-(N-Methylcarbamoyl)-4-chloropyridine;4-Chloro-N-methyl-2-pyridinecarboxamide;4-Chloropyridine-2-carboxylicacid methylamide;N-Methyl-4-chloropicolinamide; |
| EINECS: | 606-888-1 |
| Density: | 1.264 g/cm3 |
| Melting Point: | 41-43 °C |
| Boiling Point: | 317.8 °C at 760 mmHg |
| Flash Point: | 146 °C |
| Appearance: | pale-yellow solid |
| Hazard Symbols: | Xn |
| Risk Codes: | 22-36 |
| Safety: | 26 |
| PSA: | 41.99000 |
| LogP: | 1.48550 |
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- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 24484-93-3
4-Chloro-pyridine-2-carboxylic acid methyl ester
- 74-89-5
methylamine
- 220000-87-3
4-chloro-N-methylpicolinamide
| Conditions | Yield |
|---|---|
| With magnesium chloride In tetrahydrofuran at 20℃; for 2.25h; | 98.5% |
| In methanol at 0 - 5℃; for 2h; | 98% |
| magnesium chloride In tetrahydrofuran at 20℃; for 2.25h; | 98.5% |
- 74-89-5
methylamine
- 220000-87-3
4-chloro-N-methylpicolinamide
| Conditions | Yield |
|---|---|
| In tetrahydrofuran at 0 - 10℃; for 6h; Temperature; Solvent; | 98% |
| In tetrahydrofuran; methanol at 0 - 5℃; for 5h; Product distribution / selectivity; | 97% |
| In tetrahydrofuran; methanol at 0 - 5℃; Inert atmosphere; | 97% |
- 220000-87-3
4-chloro-N-methylpicolinamide
| Conditions | Yield |
|---|---|
| With methylamine In tetrahydrofuran; methanol; ethyl acetate | 97% |
| With methylamine In tetrahydrofuran; methanol; ethyl acetate | 97% |
| With methylamine In tetrahydrofuran; methanol; ethyl acetate | 97% |
| With methylamine In tetrahydrofuran; methanol; ethyl acetate | 97% |
| With methylamine In tetrahydrofuran; methanol at 0 - 3℃; for 4h; |
B
- 220000-87-3
4-chloro-N-methylpicolinamide
| Conditions | Yield |
|---|---|
| With methylamine In tetrahydrofuran; methanol; ethyl acetate | A 97% B n/a |
- 74-89-5
methylamine
- 220000-87-3
4-chloro-N-methylpicolinamide
| Conditions | Yield |
|---|---|
| In tetrahydrofuran at 0 - 20℃; for 5h; Inert atmosphere; | 94% |
| With sodium hydroxide In tetrahydrofuran at -5℃; for 3h; Temperature; Solvent; | 93% |
| In tetrahydrofuran; methanol at 0 - 3℃; for 4h; Product distribution / selectivity; | 88% |
| Conditions | Yield |
|---|---|
| In methanol at 0 - 25℃; for 6h; | 82.1% |
- 74-89-5
methylamine
- 220000-87-3
4-chloro-N-methylpicolinamide
| Conditions | Yield |
|---|---|
| Stage #1: methyl 4-chloropyridine-2-carboxylate hydrochloride With magnesium chloride In tetrahydrofuran at 20℃; for 0.0833333h; Stage #2: methylamine at 20℃; for 16.3333h; | 81% |
| Stage #1: methyl 4-chloropyridine-2-carboxylate hydrochloride With magnesium chloride In tetrahydrofuran at 20℃; for 0.0833333h; Stage #2: methylamine In tetrahydrofuran at 20℃; for 16.33h; | 81% |
- 53750-66-6
4-chloro-pyridine-2-carbonyl chloride
- 74-89-5
methylamine
- 220000-87-3
4-chloro-N-methylpicolinamide
| Conditions | Yield |
|---|---|
| In dichloromethane at 0 - 20℃; for 3.5h; | 81% |
| In dichloromethane at 0 - 20℃; for 3h; | 81% |
| With triethylamine In tetrahydrofuran; water for 3h; Cooling with ice; | 78% |
| Conditions | Yield |
|---|---|
| Stage #1: 4-chloropicolinic acid With thionyl chloride at 80℃; for 3h; Stage #2: methylamine With triethylamine In dichloromethane at 20 - 27℃; for 2h; | 46% |
| With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 48h; | 22% |
| With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃; for 3h; | |
| With hydrogenchloride In ethanol; water at 120℃; for 4h; Solvent; Temperature; | 15.2 g |
| Conditions | Yield |
|---|---|
| Stage #1: 2-Picolinic acid With thionyl chloride In N,N-dimethyl-formamide at 45 - 72℃; for 72h; Stage #2: methylamine In tetrahydrofuran; water at 0 - 20℃; for 4h; Temperature; | 39% |
| Stage #1: 2-Picolinic acid With thionyl chloride In N,N-dimethyl-formamide Stage #2: methylamine | |
| Stage #1: 2-Picolinic acid With thionyl chloride; N,N-dimethyl-formamide at 45 - 75℃; for 72h; Stage #2: methylamine In tetrahydrofuran; water at 0 - 25℃; for 4h; |
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Chemistry
Product Name: N-Methyl-4-chloropyridine-2-carboxamide
Molecular Structure of N-Methyl-4-chloropyridine-2-carboxamide (CAS NO.220000-87-3):
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Molecular Formula: C7H7ClN2O
Molecular Weight: 170.5963
Synonyms of N-Methyl-4-chloropyridine-2-carboxamide (CAS NO.220000-87-3): 4-Chloropyridine-2-carboxylic acid methylamide ; N-Methyl-4-chloro-2-pyridinecarboxamide
CAS NO: 220000-87-3
Classification Code: blocks ; Carboxes ; Pyridines ; Pyridine ; Amines ; Aromatics ; Heterocycles
Melting Point: 41-43°C
Index of Refraction: 1.547
Molar Refractivity: 42.86 cm3
Molar Volume: 134.9 cm3
Surface Tension: 45.4 dyne/cm
Density: 1.264 g/cm3
Flash Point: 146 °C
Enthalpy of Vaporization: 55.93 kJ/mol
Boiling Point: 317.8 °C at 760 mmHg
Vapour Pressure of N-Methyl-4-chloropyridine-2-carboxamide (CAS NO.220000-87-3): 0.000375 mmHg at 25°C