Detail of "22089-22-1"

CAS Number:
22089-22-1
Name:
2H-1,3,2-Oxazaphosphorin-2-amine,N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide
Molecular Structure:
Formula:
C9H18 Cl3 N2 O2 P
Molecular Weight:
323.61
Synonyms:
2H-1,3,2-Oxazaphosphorine,2-[bis(2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-, 2-oxide (8CI);3-(2-Chloroethyl)-2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine2-oxide; Asta Z 4828; Ixoten; NSC 109723; Trifosfamide; Trilofosfamida;Trilophosphamide; Triphosphamide; Trisfosfamide; Trofosfamid; Trofosfamide; Trophosphamid;Trophosphamide; Z 4828
Density:
1.35g/cm³
Boiling Point:
393.7°Cat760mmHg
Flash Point:
191.9°C
Safety:
Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. Human mutation data reported. Human systemic effects by unspecified routes: hematuria, leukopenia, and thrombocytopenia. When heated to decomposition it emits very toxic fumes of Cl⁻, NO_x, and PO_x. Details

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Cytogenetic investigations of mammals: Cytogenetic investigations of mammals. Comparison of the genetic activity of cytostatics in mammals. Roehrborn, G.; Basler, A. (Inst. Humangenet. Anthropol., Univ. Duesseldorf, Duesseldorf, Ger.). Arch. Toxicol., 38, 35-43 (English) 1977. CODEN: ATXKA8. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In the bone marrow chromosomes of mice, rats, and hamsters the relative mutagenic activity was trophosphamide (I) [22089-22-1] < isophosphamide (II) [3778-73-2] < cyclophosphamide (III) [50-18-0] 8 h after the 2nd i.p. application. The max. mutagenic activity of all 3 cytostatics was 12 h after the 2nd injection. Thereafter the aberration rate induced by III decreased quickly. The inactivation of II and I and the elimination of chromosome aberrations was delayed. Dose-effect-relationships of III in hamsters were investigated using the micronucleus test and anal. of bone marrow chromosomes. Correlations between the 2 test systems were demonstrated. Five applications of III led to a drastic increase of chromosome aberrations in bone marrow of hamsters. In spermatogonia, on the other hand, no significant increase was detectable. These differences are discussed.

Trofosfamide: Trofosfamide. Van Dyk, J. M. (Spain). Med. Actual., 13(3), 115-20 (English/Spanish) 1977. CODEN: MDACAP. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacodynamics) A review with 6 refs. is given on the uses and toxicity of trofosfamide (I) [22089-22-1], a cytostatic agent activated by liver microsomes.