Reference

Administration of silver sulfadiazine and radioactive derivatives

Administration of silver sulfadiazine and radioactive derivatives. Wysor, Michael S. (Kalil, Eugene J., USA). U.S. US 4020150 26 Apr 1977, 5 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K043-00. NCL: 424001000. APPLICATION: US 73-415637 14 Nov 1973. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 8 An aq. suspension of silver sulfadiazine (I) [22199-08-2] administered orally or s.c. in doses of 1,050 mg/kg, once daily for 5 days cured mice of Plasmodium berghei infection (malaria) even after splenectomy. Parositemia was eliminated in 1 to 3 days. The antimalarial activity of I was not inhibited by p-aminobenzoic acid indicating a mode of action different from that of the sulfonamides. Doses of 1,050 mg I/kg/day orally or s.c. were also effective against systemic Pseudomonas aeruginosa infections in mice. I and silver sulfamethoxydiazine localized in the PC-6 tumor system in the same manner as sulfadiazine. 111Ag-labeled I is therefore proposed as a neoplasm inhibitor, the localization of radiation within the tumor serving to eradicate malignant cells. No acute or chronic toxicity was obsd. in mice on administration of 1,050 mg I/kg/day for 30 days, however, i.p. administration was toxic in doses ranging from 550-1,050 mg I/kg.

Silver sulfadiazine (AgSD) resistant Pseudomonas infection in experimental burn wounds

Silver sulfadiazine (AgSD) resistant Pseudomonas infection in experimental burn wounds. Modak, S. M.; Stanford, J. W.; Bradshaw, W.; Fox, C. L., Jr. (Coll. Physicians Surg., Columbia Univ., New York, NY, USA). Panminerva Med., 25(3), 181-8 (English) 1983. CODEN: PMMDAE. ISSN: 0031-0808. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 10 The in vitro and in vivo efficacy of silver sulfadiazine (I) [22199-08-2] and other metal sulfadizaines and bactericides against several I-resistant strains of Pseudomonas aeurigonasa is reported. Apparently, there are 2 types of bacterial strains; those sensitive to I in vitro and in vivo; and, those sensitive to I in vitro but resistant to the drug in vivo. 55-56-1 and 7440-48-4 are just another two chemicals used in this study. A comparative study of the growth and pathogenic properties of these 2 different Pseudomonas strains is presented. .