Reference

Ionophoric coccidiostatics: studies of their effects on the heart of chickens

Ionophoric coccidiostatics: studies of their effects on the heart of chickens. Kaemmerer, K.; Fink, J. (Inst. Pharmakol., Toxikol. Pharm., Tieraerztl. Hochsch. Hannover, Hannover, Ger.). Dtsch. Tieraerztl. Wochenschr., 85(6), 216-20 (German) 1978. CODEN: DTTIAF. ISSN: 0012-0847. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The oral administration of the ionophoric coccidiostatic antibiotics Na monensin [22373-78-0], lasalocid [11054-70-9], and salinomycin [53003-10-4] to chickens did not affect the EKG, peripheral arterial blood pressure, or heart rate, even at doses 10-fold greater than normally used. In addn., consumption of feed treated with the antibiotics at the usual concns. did not change serum electrolytes (Na+, K+, and Ca2+) over a 72-h period. Heart rate and blood pressure in the chickens were only slightly decreased by coccidiostat doses at 375 mg/kg body wt., amts. that were 50-75-fold higher than normally applied doses and within the toxic range of the compds.

Metabolism of monensin in the steer and rat

Metabolism of monensin in the steer and rat. Donoho, A.; Manthey, J.; Occolowitz, J.; Zornes, L. (Lilly Res. Lab., Div., Eli Lilly and Co., Greenfield, Indiana, USA). J. Agric. Food Chem., 26(5), 1090-5 (English) 1978. CODEN: JAFCAU. ISSN: 0021-8561. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The metab. of 14C-labeled monensin Na (I) [22373-78-0] was studied in both cattle and rats. I was metabolized to many different compds. by both species. The metabolite pattern was qual. similar but quant. different in the 2 species. Six fecal metabolites were tentatively identified. Five resulted from O-demethylation and/or hydroxylation and one resulted from demethylation and decarboxylation. The radioactive residue in steer liver was characterized and the metabolite pattern was qual. similar to that of feces. The most abundant metabolite accounted for only 6% of the liver radioactivity.