Detail of "224785-91-5"

CAS Number:
224785-91-5
Name:
Vardenafil hydrochloride
Molecular Structure:
Formula:
C₂₃H₃₃ClN₆O₄S
Molecular Weight:
525.06
Synonyms:
Piperazine,1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-,monohydrochloride (9CI);Levitra;
Melting Point:
214-216 °C
Boiling Point:
692.2 °C at 760 mmHg
Flash Point:
372.5 °C
Appearance:
White to off-white cyrstalline solid

Famous Chemical Enterprises

Livzon
Total
Shell
Dupont
Exxonmobil
Akzonobel
Basf
Bayer
BP

Other Products

Supplier Location
Supplier Location
- China (Mainland)(16)
- India(3)
- United Kingdom(1)
Business Type
Business Type
- Lab/Research institutions(2)
- Manufacturers(0)
- Trading Company(14)
Certificates
Certificates
- ISO(1)
- Production License (0)

Please post your buying leads>>

Display：

Manufacturer
Enterprise Authentication
Suppiers of more reward points first
New supplier

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Reference

Drugs containing vardenafil hydrochloride trihydrate prepared by rehydration: Drugs containing vardenafil hydrochloride trihydrate prepared by rehydration. Serno, Peter; Grunenberg, Alfons; Ohm, Andreas; Bellinghausen, Rainer; Vollers, Eimer; Henck, Jan-Olav (Bayer Healthcare AG, Germany). PCT Int. Appl.In this study， 224785-91-5 and 330808-88-3 are also used. WO 2004006894 A1 22 Jan 2004, 42 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW, AM, AZ, BY, KG, KZ, MD, RU; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (German). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: A61K009-28. ICS: A61K031-53; A61P015-10. APPLICATION: WO 2003-EP7093 3 Jul 2003. PRIORITY: DE 2002-10232113 16 Jul 2002. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) The invention relates to a method for producing medicaments that contain vardenafil hydrochloride, essentially as trihydrate in solid form, and to medicaments that can be obtained according to this method. Tablets and coated tablets are prepd. from compns. that contain vardenafil hydrochloride with undefined water content; these tablets are contacted with humid air until vardenafil hydrochloride trihydrate is formed. Thus coated tablets were prepd. by mixing 216 g microfine vardenafil HCl, 605 g microcryst. cellulose and 43.2 g Crospovidine, followed by the addn. of 2101 g cellulose and 132 g Crospovidine; thereafter 350 g cellulose, 17.5 g highly dispersed silica and 35 g magnesium stearate were dosed. Tablets with 6 mm diam. and 87 mg wt. were pressed; they contained 5 mg vardenafil base. Tablets were coated (43.5 mg/tablet) with a suspension that included (%): hypromellose 4.5; Macrogol 400 1.5; titanium dioxide 1.23; iron oxide yellow 0.25; iron oxide red 0.02. The tablets were rehydrated in a fluidized bed granulator for 4 h at 150 m3/h air flow at 30°C and 19 g/kg water content (corresponds to 70% relative humidity). The product contains vardenafil hydrochloride trihydrate; the dissoln. takes place in 0.5 min compared to the non-rehydratized tablets with 2 min of dissoln. .

Vardenafil hydrochloride hydrate (Levitra tablets): Vardenafil hydrochloride hydrate (Levitra tablets). Marumo, Ken (Sch. Med., Keio Univ., Japan). Nippon Byoin Yakuzaishikai Zasshi, 41(1), 97-100 (Japanese) 2005 Nippon Byoin Yakuzaishikai. CODEN: NBYZEB. ISSN: 1341-8815. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review on the vardenafil hydrochloride hydrate (levitra), a phosphodiesterase type 5 inhibitor, for the treatment of erectile dysfunction, discussing developmental history, the structure, pharmacol., clin. effects, major adverse effects, and drug interactions and contraindications.Except for chemicals metioned above, 224785-91-5 and 9068-52-4 are also used. .

Detail of "224785-91-5"

Vardenafil hydrochloride

Famous Chemical Enterprises

Related products

Other Products

Supplier Location

Business Type

Certificates

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

CAS No.224785-91-5 Vardenafil hydrochloride

Reference