Reference

4H-1,4-Benzothiazines and their use as lipoxygenase inhibitors

4H-1,4-Benzothiazines and their use as lipoxygenase inhibitors. Niemers, Ekkehard; Gruetzmann, Rudi; Mardin, Mithat; Busse, Wolf Dieter; Meyer, Horst (Bayer A.-G. , Fed. Rep. Ger.). Ger. Offen. DE 3229121 A1 9 Feb 1984, 28 pp. (German).In this article, certain chemicals are used. Some of their cas registry numbers are 718-08-1 and 22502-03-0 (Germany). CODEN: GWXXBX. CLASS: IC: C07D279-16; C07D417-04; A61K031-54. APPLICATION: DE 82-3229121 4 Aug 1982. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 The title compds. [I; R = H, cyano, COR5, (un)substituted aryl, heteroaryl; R1 = (un)substituted aryl; R2 = H, (un) substituted alkyl; R3,R4 = H, alkoxy, cyano, NO2, OH, acyloxy, alkyl- or arylsulfonyl, halo, (un)substituted alkyl; R5 = amino, cycloalkyloxy, substituted alkoxy] were prepd. Thus, 2-H2NC6H4SH was refluxed 2 h in Me2SO with MeCOCH2CO2CH2CH2CN to give 39% I (R = CO2CH2CH2CN, R1 = Me, R2-R4 = H) (II). II inhibited lipoxygenase in vitro with a min. inhibitory concn. of 5 ′ 10-7 - 10-6 g/mL. .