Detail of "22609-73-0"

Reference

Analysis of calcium antagonists

Analysis of calcium antagonists. II. Nifedipine. Eiden, Fritz; Braatz-Greeske, Karin (Munich, Fed. Rep. Ger.).Chemicals with cas numbers 593-51-1 and 88434-71-3 also play role. Dtsch. Apoth.-Ztg., 123(42), 2003-9 (German) 1983. CODEN: DAZEA2. ISSN: 0011-9857. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 27 The nitrophenyldihydropyridines nifedipine [21829-25-4] and niludipine [22609-73-0] can be identified by chromatog. on silica gel 60F254 plates with cyclohexane-CHCl3-Et2NH (:15) with UV detection; the method also is suitable for their oxidn. products. Color reactions (redn. of NO2 group and reaction with BzCl and FeCl3; reaction with NaOH in DMSO soln; or reaction with CrO2) can also be used for identification. Gas chromatog. on 5% SE-30 on Chromosorb AWDMCS at 280° with flame-ionization detection was suitable for qual. anal. For quant. measurement, high-pressure liq. chromatog. on m Bondapak C18-NH2 with CHCl3 mobile phase and UV detection or oxidimetric titrn. with ceric ammonium sulfate and ferroin indicator were satisfactory. The use of thin-layer and liq. chromatog. to identify and measure the nifedipine and other ingredients in Adalt capsules is described. .

Reversal of acquired resistance to vinca alkaloids and anthracycline antibiotics by calcium-channel blockers and calmodulin inhibitors

Reversal of acquired resistance to vinca alkaloids and anthracycline antibiotics by calcium-channel blockers and calmodulin inhibitors. Tsuruo, Takashi (Cancer Chemother. Cent., Japanese Found. Cancer Res., Japan). Gan to Kagaku Ryoho, 11(3, Pt. 2), 750-9 (Japanese) 1984.Several reagents with their cas registry numbers 42399-41-7 and 57-22-7 are used here. CODEN: GTKRDX. ISSN: 0385-0684. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Calcium-channel blockers and calmodulin inhibitors enhanced the intracellular levels of vincristine [57-22-7] and adriamycin (VCR) [23214-92-8] in tumor cells, esp. in drug-resistant mouse and human tumor cells, by inhibiting their outward transport. The approach using calcium modifiers has the following advantages:. (1) Reversal of acquired resistance to vinca alkaloids and anthracyclic antibiotics can be attained. Calcium-channel blockers such as verapamil [52-53-9], diltiazem [42399-41-7], nicardipine [55985-32-5], niludipine [22609-73-0], and nimodipine [66085-59-4], at doses of 30-125 mg/kg administered daily for 10 days with VCR (10-200 mg/mg) enhanced the chemotherapeutic effect of VCR (40-50% increase in life span) in P388/VCR-bearing mice. The calcium-channel blockers also enhanced the therapeutic effect of ADM in ADM-resistant P388-bearing mice. (2) The approach is also effective for the reversal of the inherent resistance of tumor cells to anticancer agents. Less sensitive tumor cells became more susceptible to VCR and the heterogeneity in drug sensitivity among tumor clones was circumvented. .