Detail of "2276-90-6"

CAS Number:
2276-90-6
Name:
Benzoic acid,3-(acetylamino)-2,4,6-triiodo-5-[(methylamino)carbonyl]-
Superlist Name:
Iotalamic acid
Molecular Structure:
Formula:
C11H9 I3 N2 O4
Molecular Weight:
613.91
Synonyms:
Isophthalamicacid, 5-acetamido-2,4,6-triiodo-N-methyl- (7CI,8CI); 5-Acetamido-2,4,6-triiodo-N-methylisophthalamicacid; 5-Acetylamino-2,4,6-triiodo-N-methyl-3-isophthalamic acid; Cysto ConrayII; Iotalamic acid; Iothalamic acid; MI 216; Methalamic acid
EINECS:
218-897-4
Density:
2.54 g/cm³
Melting Point:
285 C
Boiling Point:
520.2 °C at 760 mmHg
Flash Point:
268.4 °C
Solubility:
Insoluble particular

Display：

Molecular formula: C11H9I3N2O4 Package: 25kg/drum

392 Integral
392

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Radiation sensitization by membrane-specific drugs: Radiation sensitization by membrane-specific drugs. Shenoy, M. A.; George, K. C.; Srinivasan, V. T.; Singh, B. B.; Sundaram, K. (Bio-Med. Group, Bhabha At. Res. Cent., Bombay, India). Modif. Radiosensitivity Biol. Syst., Proc. Advis. Group Meet., Meeting Date 1975, 131-40. IAEA: Vienna, Austria. (English) 1976. CODEN: 35WGA2. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 3, 8 Escherichia coli was sensitized to 60Co .gamma.-rays by lignocaine [137-58-6], tetracaine [136-47-0], meprobamate [57-53-4], Na pentobarbitone [57-33-0], and chlorpromazine [50-53-3] under hypoxic conditions. Sensitization by chlorpromamzine was due to short-lived intermediates formed by the reactions of OH radicals, and to membrane damage. Subsequent addn. of procaine-HCl (I) [51-05-8] after irradn. presumably fixed the membrane damage and also inhibited the rejoining of DNA single-strand breaks, thus enhancing the action of chlorpromazine. However, the radiosensitization of mouse fibrosarcoma in vivo by iothalamic acid [2276-90-6] was not enhanced by subsequent injection of I followed by a 2nd radiation, compared to animals receiving the 2nd irradn. without I.

Effect of iodinated opaque media on coagulation, fibrinolysis, and blood platelets: Effect of iodinated opaque media on coagulation, fibrinolysis, and blood platelets. Schulze, B.; Riester, P.; Blanke, D.; Fees, K.; Lehnard, G. (Klin. Poliklin. Strahlenther. Roentgendiagn., Philipps Univ., Marburg, Ger.). Arzneim.-Forsch., 27(11), 2128-33 (German) 1977. CODEN: ARZNAD. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Iodipamide [606-17-7], iothalamate [2276-90-6], and diatrizoate [117-96-4] added to std. human plasma produced dose-dependent decreases in fibrinogen, prothrombin [9001-26-7], and plasminogen [9001-91-6] levels. These agents also caused thrombocytopenia and released ADP from platelets and erythrocytes. These results were discussed in terms of side effects produced by these agents.