Detail of "22802-67-1"

Reference

Synthesis of new antidiabetic agent KRP-297

Synthesis of new antidiabetic agent KRP-297. Wang, Qinghe; Wang, Qianli; Yan, Dong; Wang, Zhibo; Cheng, Maosheng (College of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, Peop. Rep. China).Several reagents with their cas registry numbers 22802-67-1 and 186312-73-2 are used here. Zhongguo Yiyao Gongye Zazhi, 34(7), 313-314 (Chinese) 2003 Zhongguo Yiyao Gongye Zazhi Bianjibu. CODEN: ZYGZEA. ISSN: 1001-8255. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 The antidiabetic agent KRP-297 was synthesized by reducing Me 2-methoxy-5-nitrobenzoate with SnCl2, diazotizing with NaNO2/HBr, Meerwein arylating with Et acrylate in the presence of Cu2O, cyclizing with thiourea in the presence of Na acetate, hydrolyzing, and amidating with 4-trifluoromethyl benzylamine with an overall yield of 24.6%. .