Detail of "2304-98-5"

Reference

Immuno-regulating peptides

Immuno-regulating peptides. I. Synthesis and structure-activity relationships of thymopentin analogs. Kisfaludy, Lajos; Nyeki, Olga; Schon, Istvan; Denes, Laszlo; Szporny, Laszlo; Hajos, Gyorgy; Szende, Bela (Chem. Works, Gedeon Richter, Ltd., Budapest, Hung.). Hoppe-Seyler's Z. Physiol. Chem., 364(8), 933-40 (English) 1983. CODEN: HSZPAZ. ISSN: 0018-4888. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 15, 34 Seventeen peptides, related to the thymopoietin pentapeptide, L-arginyl-L-lysyl-L-aspartyl-L-valyl-L-tyrosine (thymopentin) were synthesized by the stepwise strategy in soln. 6327-59-9 and 2304-98-5 which are cas registry numbers of chemicals are mentioned. Of these, L-arginyl-L-lysyl-L-aspartic acid [85465-82-3] and L-arginyl-L-lysyl-L-aspartyl-L-valine [85466-18-8], shortened from the C-terminus of the pentapeptide, exhibit significant immuno-stimulating potencies, exceeding those of thymopentin, both in vitro and in vivo immunol. tests. Studies on the structure-activity relationships suggest that the potential active site of thymopoietins is very sensitive to the N- and C-terminal elongations of the peptide chain. For thymic hormones, an active site carrying cumulative chem. signals is proposed instead of well-defined active centers. .

Peptide derivatives

Peptide derivatives. Atherton, Frank Ratcliffe; Hall, Michael John; Hassall, Cedric Herbert; Lambert, Robert Wilson; Ringrose, Peter Stuart (Hoffmann-La Roche, F., und Co. A.-G., Switz.). Ger. Offen. DE 2730549 19 Jan 1978, 25 pp.Except for chemicals metioned above, 2304-98-5 is also used. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07F009-65. PRIORITY: GB 76-29102 13 Jul 1976. DOCUMENT TYPE: Patent CA Section: 34 (Synthesis of Amino Acids, Peptides, and Proteins) Section cross-reference(s): 29, 63 H-L-pyroGlu-NHCHRCO(NHCHR1CO)nNHCHR2P(O)(OH)R3 (R, R1, and R2 = amino acid side chains; R3 = OH, Me; n = 0-3; configurations at CHR and CHR1 are L when R and R1 1 H and R at CHR2 when R2 1 H) and their salt, useful as bactericides, were prepd. Thus, H-L-pyroGlu-OC6H2Cl3-2,4,5 was coupled to (R)-H-L-Ala-NHCHMeP(O)(OH)2 to give (R)-H-L-pyroGlu-L-Ala-NHCHMeP(O)(OH)2 (I) (isolated as benzylamine salt). I had a min. There are some commonly used reagents like 2304-98-5 in this article. inhibitory concn. of 1.0 mg/mL against Streptococcus faecalis. ..