Detail of "23095-76-3"

Reference

Mass fragmentographic determination of d- and l-chlorpheniramine with aid of the stable isotope technique

Mass fragmentographic determination of d- and l-chlorpheniramine with aid of the stable isotope technique. Miyazaki, Hiroshi; Abuki, Hideo (Pharm.Several substances are used for example 23095-76-3 and 2438-32-6 which are their cas registry numbers. Div., Nippon Kayaku Co., Tokyo, Japan). Chem. Pharm. Bull., 24(10), 2572-4 (English) 1976. CODEN: CPBTAL. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) To investigate the pharmacokinetics of d-chlorpheniramine maleate (d-CPA)(I maleate) [2438-32-6] and its l-isomer [23095-76-3], d-CPA-d6 and l-CPA-d0 were administered orally and simultaneously to healthy adult volunteers. Both isomers in the serum were measured by chem. ionization-mass fragmentog. using dl-CPA-d13 as the internal std. The concn. of d-isomer was higher than that of l-isomer and the ratio (d/l) of both isomers was 1.9-3.1, and the biol. half-lives of d- and l-isomer were 24 and 15 hr, resp. .

The optical resolution of racemic chlorpheniramine and its stereoselective pharmacokinetics in rat plasma

The optical resolution of racemic chlorpheniramine and its stereoselective pharmacokinetics in rat plasma. Sakurai, Eiichi; Yamasaki, Seiji; Iizuka, Yukisumi; Hikichi, Noboru; Niwa, Hiroshi (Dep. Pharm. I, Tohoku Coll. Pharm., Sendai 981, Japan). J. Pharm. Pharmacol., 44(1), 44-7 (English) 1992. CODEN: JPPMAB. ISSN: 0022-3573. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) An ovomucoid-conjugated column has been developed for the chiral stationary-phase liq. chromatog. resoln. of racemic chlorpheniramine with a quantitation limit of 0.05 mg/mL. The assay was used to study the stereoselective kinetics of chlorpheniramine enantiomers in rats. After bolus i.v. administration of racemic chlorpheniramine maleate (20 mg/kg), plasma concn. of the (-)-form was higher than that of the (+)-form. In the elimination phase, the concns. of (+)- and (-)-chlorpheniramine in the plasma declined biexponentially with the half-lives of 18.2 and 50.0 min, resp. Although there was no difference in blood-to-plasma concn. 7054-11-7 and 23095-76-3 are just another two chemicals used in this study. ratio of both enantiomers, the apparent total blood clearance of (+)-chlorpheniramine was twice as large as that of the (-)-isomer. Binding of (-)-chlorpheniramine to rat plasma protein was stronger than that of (+)-chlorpheniramine, suggesting stereoselective pharmacokinetics may be due to a difference in the plasma protein binding. .