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| CAS No.: | 2315-02-8 |
|---|---|
| Name: | Oxymetazoline hydrochloride |
| Article Data: | 1 |
| Molecular Structure: | |
|
|
|
| Formula: | C16H24 N2 O . Cl H |
| Molecular Weight: | 296.84 |
| Synonyms: | Phenol,3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl-,monohydrochloride (9CI); Phenol,6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-, hydrochloride (7CI);Phenol, 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-,monohydrochloride (8CI); 2,6-Dimethyl-4-tertiarybutyl-3-hydroxyphenyl)methylimidazolinehydrochloride; 2-(4-tert-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoliniumchloride; 4-Way Nasal 12 Hour Spray; 4-Way Nasal Spray;6-tert-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol hydrochloride; Afrazine;Afrin; Afrin hydrochloride; Allerest 12 Hour Nasal Spray; Dristan Long-LastingNasal Mist; Duration; Duration 12 Hour Nasal Spray; H 990; Iliadin; Nafrine;Nasivin; Neo-Synephrine 12 Hour; Neo-Synephrine 12 Hour NTZ; Nostrilla;Ocuclear; Oxilin; Oxymetazoline chloride; Oxymetazoline hydrochloride; Respir;Sch 9384 |
| EINECS: | 219-015-0 |
| Density: | 1.08g/cm3 |
| Melting Point: | approximate 300℃ (dec.) |
| Boiling Point: | 431.9°Cat760mmHg |
| Flash Point: | 215°C |
| Appearance: | Off-White to Pale Yellow Solid |
| Hazard Symbols: |
 T+
|
| Risk Codes: | R28 |
| Safety: | Poison by ingestion, subcutaneous, intraperitoneal, and intravenous routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and HCl. An adrenergic agent. |
| Transport Information: | UN 2811 |
| PSA: | 44.62000 |
| LogP: | 3.41710 |
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- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 2315-02-8
Oxymetazoline hydrochloride
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: ammonium hydroxide / 25 - 30 °C 2: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 5 °C 3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 18 h / 20 - 30 °C / Inert atmosphere 4: hydrogen; palladium 10% on activated carbon / methanol View Scheme |
- 2315-02-8
Oxymetazoline hydrochloride
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: ammonium hydroxide / 25 - 30 °C 2: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 5 °C 3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 18 h / 20 - 30 °C / Inert atmosphere View Scheme |
| Conditions | Yield |
|---|---|
| With ammonium hydroxide at 25 - 30℃; |
- 2315-02-8
Oxymetazoline hydrochloride
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: ammonium hydroxide / 25 - 30 °C 2: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 5 °C View Scheme |
- 2315-02-8
Oxymetazoline hydrochloride
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: ammonium hydroxide / 25 - 30 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 5 °C 3.1: sodium hydride / tetrahydrofuran / 0 - 5 °C 3.2: 2 h / 0 - 5 °C View Scheme |
- 2315-02-8
Oxymetazoline hydrochloride
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1.1: ammonium hydroxide / 25 - 30 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 5 °C 3.1: sodium hydride / tetrahydrofuran / 0 - 5 °C 3.2: 2 h / 0 - 5 °C 4.1: hydrogen; palladium 10% on activated carbon / methanol / 12 h / 25 - 30 °C View Scheme |
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Chemistry
IUPAC Name: 6-Tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol hydrochloride
Molecular Formula: C16H25ClN2O
Formula Weight: 296.84g/mol
EINECS: 219-015-0
Flash Point: 215 °C
Enthalpy of Vaporization: 71.41 kJ/mol
Boiling Point: 431.9 °C at 760 mmHg
Vapour Pressure: 4.59E-08 mmHg at 25°C
Form: solid
Color: white
H bond acceptors: 3
Freely Rotating Bonds: 4
Synonyms of Afrin hydrochloride (2315-02-8): 2-(4-t-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoliniumchloride ; 2,6-Dimethyl-2-(4-tertiarybutyl-3-hydroxyphenyl)methylimidazolinehydrochlori ; 6-t-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl-phenohydrochloride ; 6-t-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenolhydrochloride ; Afrazine ; Duration ; Iliadinhydrochloride
Product Categories of Afrin hydrochloride (2315-02-8): Adrenoceptor
Structure of Afrin hydrochloride (2315-02-8):
Uses
It is used in local vasoconstriction drugs.
It is also used as allergic conjunctivitis, allergic rhinitis, acute and chronic
rhinitis and so on.
Toxicity Data With Reference
| 1. | ipr-rat TDLo:1800 µg/kg (1-3D preg):REP | IJMRAQ Indian Journal of Medical Research. 67 (1978),478. | ||
| 2. | orl-rat LD50:680 µg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 30 (1980),1760. | ||
| 3. | scu-rat LD50:1630 µg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 11 (1961),1016. | ||
| 4. | ivn-rat LD50:1070 µg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 11 (1961),1016. | ||
| 5. | orl-mus LD50:4700 µg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 1 (1967),74. | ||
| 6. | ipr-mus LD50:48 mg/kg | FRPPAO Farmaco, Edizione Pratica. 21 (1966),204. | ||
| 7. | scu-mus LD50:34 mg/kg | ARZNAD Arzneimittel-Forschung. Drug Research. 11 (1961),1016. | ||
| 8. | ivn-mus LD50:2700 µg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 1 (1967),74. |
Safety Profile
Hazard Codes: T+ 
Risk Statements: 28
R28: Very toxic if swallowed.
Safety Statements: 22-28-36/37/39-45
S22: Do not breathe dust.
S28: After contact with skin, wash immediately with plenty of soap-suds.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
Hazard Class: 6.1(a)
Specification
It will be kept in ventilated, cold ,dry place,and separately from
raw materials and food.