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| CAS No.: | 23239-51-2 |
|---|---|
| Name: | Ritodrine hydrochloride |
| Molecular Structure: | |
|
|
|
| Formula: | C17H22ClNO3 |
| Molecular Weight: | 323.82 |
| Synonyms: | Benzenemethanol,4-hydroxy-a-[(1R)-1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-,hydrochloride, (aS)-rel-(9CI);Benzenemethanol, 4-hydroxy-a-[1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-, hydrochloride, (R*,S*)-;Benzyl alcohol, p-hydroxy-a-[1-[(p-hydroxyphenethyl)amino]ethyl]-, hydrochloride, erythro- (8CI);DU21220;Miolene;NSC 291565;Pre-Par;Prempar;Ritodrine hydrochloride;Utemerin;Utopar;Yutopar; |
| EINECS: | 245-514-8 |
| Density: | 1.213 g/cm3 |
| Melting Point: | 192-196 °C |
| Boiling Point: | 512.3 °C at 760 mmHg |
| Flash Point: | 175.6 °C |
| Appearance: | off-white solid |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 22 |
| Safety: | 36 |
| PSA: | 72.72000 |
| LogP: | 3.54490 |
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This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
Chemistry
Molecular Structure of Ritodrine hydrochloride (CAS NO.23239-51-2):
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IUPAC Name: 4-[2-[[(1R,2S)-1-Hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol hydrochloride
Molecular Weight: 323.81448 [g/mol]
Molecular Formula: C17H22ClNO3
H-Bond Donor: 5
H-Bond Acceptor: 4
Density: 1.213 g/cm3
Melting point: 192-196 °C
Boiling point: 512.3 °C at 760 mmHg
Flash point: 175.6 °C
Enthalpy of Vaporization: 82.49 kJ/mol
Vapour Pressure: 2.55E-11 mmHg at 25 °C
Appearance: Off-White Solid
EINECS: 245-514-8
Product Categories: Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals
Classification Code: Drug / Therapeutic Agent; Human Data; Relaxant [smooth muscle]; Reproductive Effect
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intravenous | 128mg/kg (128mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984. |
| dog | LD50 | oral | 2458mg/kg (2458mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: CHANGE IN RATE | Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984. |
| mouse | LD50 | intramuscular | 433mg/kg (433mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984. |
| mouse | LD50 | intraperitoneal | 265mg/kg (265mg/kg) | Yiyao Gongye. Pharmaceutical Industry. Vol. 16, Pg. 122, 1985. | |
| mouse | LD50 | intravenous | 69mg/kg (69mg/kg) | Yiyao Gongye. Pharmaceutical Industry. Vol. 16, Pg. 122, 1985. | |
| mouse | LD50 | oral | 687mg/kg (687mg/kg) | Yiyao Gongye. Pharmaceutical Industry. Vol. 16, Pg. 122, 1985. | |
| mouse | LD50 | subcutaneous | 815mg/kg (815mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BLOOD: CHANGES IN SPLEEN SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984. |
| rat | LD50 | intramuscular | 910mg/kg (910mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984. |
| rat | LD50 | intraperitoneal | 330mg/kg (330mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LIVER: OTHER CHANGES BLOOD: CHANGES IN SPLEEN | Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984. |
| rat | LD50 | intravenous | 83mg/kg (83mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BLOOD: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984. |
| rat | LD50 | oral | 1840mg/kg (1840mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: OTHER CHANGES | Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984. |
| rat | LD50 | subcutaneous | 980mg/kg (980mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BLOOD: CHANGES IN SPLEEN | Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 5704, 1984. |
| women | TDLo | intravenous | 14508ug/kg/15 (14.508mg/kg) | British Medical Journal. Vol. 2, Pg. 1194, 1978. |
Safety Profile
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Human and experimental teratogen. Human and experimental reproductive effects. Human systemic effects: metabolic acidosis. When heated to decomposition it emits toxic fumes of NOx and HCl.
Hazard Codes: 
Xn
Risk Statements:22
22:Harmful if swallowed
Safety Statements:36
36:Wear suitable protective clothing
WGK Germany:3
RTECS:DO6524000
Specification
Ritodrine hydrochloride (CAS NO.23239-51-2), its Synonyms are N-(p-Hydroxyphenethyl)-4-hydroxynorephedrine hydrochloride ; (R*,S*)-4-Hydroxy-alpha-[1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]benzyl alcohol hydrochloride ; Benzenemethanol, 4-hydroxy-alpha-(1-((2-(4-hydroxyphenyl)ethyl)amino)ethyl)-, hydrochloride, (R*,S*)- ; Ritodrine HCl .