Reference

Hemostatic antibacterial composition comprising Cephalonoplos extract and benzalkonium chloride

Hemostatic antibacterial composition comprising Cephalonoplos extract and benzalkonium chloride. Thomas, Mini; Manke, Ajit Sitaram; Khaiat, Alain; Hart, William ( Johnson & Johnson Limited, India). PCT Int. Appl. WO 2004103264 A2 2 Dec 2004, 17 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: A61K. APPLICATION: WO 2004-IN141 21 May 2004. PRIORITY: CN 2003-136535 22 May 2003. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) This invention relates to a hemostatic antibacterial compn. which comprises an ext. of Cephalonoplos segetum and benzalkonium chloride. Preferably a local anesthetic and a surfactant are added to this compn. This synergistic compn. decreases blood coagulating time considerably. Local anesthetic used may be lidocaine hydrochloride. Medicament-contg. strips, pouches and compresses are included in this invention. Method of making this synergistic compn. 64-17-5 and 23239-88-5 are cas registry numbers of chemicals which are used as reagents here. is by admixing the components under stirring. Medicament contg. cotton or non-woven strips with the compn. and making the desired products therewith are also described. For example, a hemostatic antibacterial soln. was obtained by mixing under stirring C. segetum ext. powder (1 g), chloride (0.2 g of 50% benzalkonium chloride), sodium chloride (0.61 g), and lidocaine hydrochloride (2 g) with purified water (96.19 g). Compresses were made by soaking nonwoven strips in the soln. and sealing them in aluminum foil. .