Detail of "23249-97-0"

Reference

Esters of 3-(2-hydroxyethyl)-4(3H)-quinazolinone with analgesic activity

Esters of 3-(2-hydroxyethyl)-4(3H)-quinazolinone with analgesic activity. Fisnerova, L.; Grimova, J.; Roubal, Z. 107250-13-5 and 16529-06-9 are also occured in this study.; Maturova, E.; Brunova, B. (Vyzk. Ustav Farm. Biochem., Prague, Czech.). Cesk. Farm., 35(10), 447-50 (Czech) 1986. CODEN: CKFRAY. ISSN: 0009-0530. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 28 A series of 13 new compds. (I; R = substituted Ph, substituted benzyl, pyridinyl, substituted benzimidazolyl, etc.), esters of 3-(2-hydroxyethyl)-4(3H)-quinazolinone [2981-86-4] and 4-chlorophenylacetic [1878-66-6], 4-methoxyphenylacetic [104-01-8], 3,4-dimethoxyphenylacetic [93-40-3], phenoxyacetic [122-59-8], 4-chlorophenoxyacetic [122-88-3], 2,2-dimethyl-2-(4-chlorophenoxy)acetic [882-09-7], 4-chlorobenzoic [74-11-3], diphenylacetic [117-34-0], benzilic [76-93-7], nicotinic [59-67-6], isonicotinic [55-22-1], 2-(2-benzimidazolyl)benzoic [16529-06-9], and 3-(2-benzimidazolyl)propionic acid [23249-97-0] was prepd. Synthesis was performed by a procedure based on the reaction of acid imidazolides developed from the acids and 1,1-carbonyldiimidzole with hydroxy quinazolinone derivs., and by a procedure based on the reaction of the Na salt of the acid with 3-(2-iodoethyl)-4(3H)-quinazolinone [107249-90-1]. The substances were tested primarily as to their analgesic effectiveness in mice. The most important analgesic activity with very low acute toxicity (in comparison with the pyrazolone analgesic agent aminophenazone) was shown by the esters of 2-(2-benzimidazolyl)benzoic acid, i.e., 3-[2-[2-(2-benzimidazolyl)benzoyloxy]ethyl]-4(3H)-quinazolinone [101388-47-0]. .

Benzimidazole derivative

Benzimidazole derivative.Some chemicals with cas registry numbers like 62668-12-6 and 23249-97-0 are also used. (Laboratorios Lafarquim S. A., Spain). Span. ES 412685 16 May 1976, 8 pp. (Spanish). (Spain). CODEN: SPXXAD. CLASS: IC: C07D. APPLICATION: ES 19730315. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) 2-Benzimidazolepropionic acid Et ester (I) or its HCl salt were prepd. by esterification of the acid with EtOH in the presence of HCl or SOCl2 or by use of acetone or DMF as solvent in the presence of Et3N-ClCO2Et or dicyclohexylcarbodiimide. .