Reference

On the pharmacokinetics of sulfonamide-trimethoprim combination orally administered to geese

On the pharmacokinetics of sulfonamide-trimethoprim combination orally administered to geese. Romvary, Attila; Horvay, Magdolna S. (Dep. Pharmacol. Toxicol., Univ. Vet. Sci., Budapest, Hung.). Acta Vet. Acad. Sci. Hung., 26(2), 173-82 (English) 1977. CODEN: AVASAX. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Orally administered sulfachloropyridazine sodium [23282-55-5] and sulfamethoxazole [723-46-6] were eliminated from geese in a relatively short time, their pharmacokinetics resembling the elimination rate of trimethoprim [738-70-5]. The synergistic antimicrobial activity and similar pharmacokinetics suggest the use of these sulfonamides in combination with trimethoprim for the treatment of pasteurellosis in geese. Although other sulfonamides may also be effective in the presence of trimethoprim, they are not recommended because they are eliminated more slowly than trimethoprim. Consequently the residual sulfonamide is inactive against Pasteurella after the trimethoprim is gone, the presence of such sulfonamides promotes the development of resistance, and the levels of accumulated sulfonamides restrict the frequency with which the chemotherapeutic mixt. can be applied.

Synergistic antibacterial compositions containing trimethoprim, a sulfonamide and phenoxyethanol

Synergistic antibacterial compositions containing trimethoprim, a sulfonamide and phenoxyethanol. Stolar, Maurice E. (ABIC Ltd., Israel). U.S. US 4470978 A 11 Sep 1984, 4 pp. Cont.-in-part of U.S. Ser. 214,736, abandoned. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-625; A61K031-63; A61K031-505; A61K031-085. NCL: 424229000. APPLICATION: US 82-427891 28 Sep 1982. PRIORITY: IL 78-55214 25 Jul 1978; US 79-59382 20 Jul 1979; US 80-214736 9 Dec 1980. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 Synergistic antibacterial compns. are prepd. from sulfa drugs and trimethoprim (I) [738-70-5] and phenoxyethanol [122-99-6]. Addn. of phenoxyethanol to the I-sulfonamide mixts. increases the synergistic activity. The ratio of I to the sulfa drug to phenoxyethanol is 1:3-.3-0.6. Thus, a compn. was prepd. contg. Na sulfachloropyridazine [23282-55-5] 39.4, I 7.8, phenoxyethanol 1.44 and sugar 13.14 g. The effectiveness of the mixt. was demonstrated in chickens.